Appendix: Added Splash I-VIa

[michael edward badolato jr]

Appendix: Added Splash I-VI

I. To Run or Not to Run

McMaster Daily News 2011:

"...Endurance exercise can stop you from looking and feeling old and may even help you live longer, a study by McMaster University researchers has found.

The study, published in the prestigious science journal Proceedings if the National academy of Sciences, found that premature aging in nearly every organ in the body was completely prevented in mice that ran on a treadmill three times a week for five months [45 minutes each time].

...Mitochondria are unique in that they have their own DNA. It has been thought that lifelong accumulation of mitochondrial DNA mutations leads to an energy crisis that results in a progressive decline in tissue and organ function, ultimately resulting in aging. But the study on genetically-disadvantaged mice found those who had endurance exercise training [running on a treadmill] three times a week looked as young as healthy mice while their sedentery siblings were balding, greying, physically inactive, socially isolated and less fertile..."

Safdar A. et al. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. PNAS 108;10:4135-4140