Multiple Chemical Sensitivity Etiology

Airway Genetics and Ambient Combustion Aerosol

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a) C.G. Jung's psychological types (1921) R.F.C. Hall translatiom published by Princeton University Press, early but highly regarded - written by a principle founder of modern Psychology - and from which can be atributed wide use of the terms introversion and extraversion - is an organization of 8 principle types according to dominance of the feeling, thinking, intuition, or sensation function in either the introverted or extraverted attitude.
b) Jung further refines the types by recognizing a function of secondary importance - for example introverted intuition (a perceptive function) if in the primary dominant position is paired to either introverted thinking or feeling as the secondary complementary judgement function - making a total of 16 types.
c) A psychological portrait emerges - cumulative image of typical characteristics - while individual features are effaced.
d) Occurring with randomly equal distribution and distinctness - Jung concluded the type phenomenon must have a genetic foundation.
e) Jung reported hypersensitivity of the sense organs only among the genetically determined introverted intuitives - strongly indicating a shared genetic basis of physiological and psychological features.
f) Jung referred to symptoms accompanying hypersensitivity as hypochondriacal - therefore MCS should be considered a psychiatric illness and modern scientific findings of the physiological mechanisms should be dismissed.

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d) is consistent with heritability of respiratory symptoms related to perfume reported by Elberling 2009.
e)
f) Jung's introverted intuition is one of 8 principle types - prevalence of MCS has been estimated 3.1-6.3% doctor diagnosed and 11-16% self reported (Caress 2004, Kreutzer 1999) - a large minority.
g) Greater genetic sensitivity of a large population subset suggests vulnerability rather than a defect - not prepared for hazardous chemical exposure 100% of the time - the continuous ACA and other chemicals.
h) It is best to dismiss MCS as a poorly understood sickness behavior or genetic deletion in metabolizing enzymes - even though evidence indicates otherwise.

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a) Emission plume modeling has been applied to power plants.
b) Effective stack height is the actual plus upward motion of pollution due to heat - a distinction relevant to tall smokestacks with high volume release but making little difference concerning vehicle and residential sources.
c) Several plume shapes are possible - principle are neutral coning and inversion limited mixing.
d) Neutral cone is achieved most afternoons - horizontal with the wind - approx equal projection of pollutants down and upward - atmosphere cooler with height - no restrictive ceiling. Inversion limited mixing occurs most evenings through midmorning - upward movement is flattened by warm air over cold at 600-1500 feet.
e) Effective stack height of tailpipe and residential chimney emission is a very short distance upward before horizontally projected - an immediate continuous ground level concentration.
f) Tailpipe and residential chimney emissions rise vertically due to heat with no downward movement - therefore ground level concentrations of the ACA are not significant.

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a) MCS and oil refinery emissions - acute and masked symptomatology, immediate and delayed - most of the time within 30, somewhat frequently 30-70, and occasionally at 70-400 miles.
b) MCS city, metro, or community of woodstoves, acute and masked, immediate and delayed - most of the time within 30, often 30-70, and less frequently at 70-400 miles.
c) MCS and a single vehicle, acute and masked, immediate and delayed - at distances up to and beyond 5 miles downwind in a usual horizontal cone.

d) MCS - horizontal coning from source areas and each vehicle or chimney - continuous exposure to the ACA - acute and masked symptomatology, immediate and delayed - all the time ( ).
e) Oil refinery, residential, and vehicle emissions - smokestack, chimney, and tailpipe - rise due to heat - resulting in low ground level concentrations - therefore od not elicit symptoms among MCS people.

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a) Indoor concentrations of ambient air pollutants - including the ACA - are significant in a closed house ( ).
b) Environmental filter chambers - chemical provocation tests unethical as a diagnostic tool - although MCS people usually react to incidental exposures in ways that can be observed and measured - it takes several days within before the influence of masking and delayed symptoms is removed.
c) Continuous ACA - acute and masked symptomatology, immediate and delayed - may confound attempts to associate symptoms with specific exposures or weigh their relative significance.
d) MCS people should demonstrate reproducibility of symptoms to specific exposures in affirming diagnosis - there are no significant confounding influences.

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