MCS 7 Kimata 2004: Neurogenic Inflammation Measured

[michael edward badolato jr]

Quotations in the forum MCS 5 Research Paper described the airway epithelial damage found in MCS patients. MEGGS W.J. HYPOTHESIS FOR INDUCTION AND PROPAGATION OF CHEMICAL SENSITIVITY BASED ON BIOPSY STUDIES EHP 105:2; 473-78 1997. It was believed certain inflammatory substances would be elevated in those patients.
 
In 2003 plasma measurements confirmed chronically elevated mediators of inflammation occurring as a result of airway epithelial damage and exposed C fiber nerves -

KIMATA, H. EFFECT OF EXPOSURE TO VOLATILE ORGANIC COMPOUNDS ON PLASMA LEVELS OF NEUROPEPTIDES, NERVE GROWTH FACTOR, AND HISTAMINE IN PATIENTS WITH SELF REPORTED MULTIPLE CHEMICAL SENSITIVITY. INT JRNL OF HYG AND ENV H 207;2:159-63 2004:

"plasma levels of SP (substance P), VIP (vasoactive intestinal peptide), and NGF (nerve growth factor), but not histamine are significantly (p<0.01 by ANOVA) elevated in sMCS patients...

exposure to VOC further increased levels of SP, VIP, and NGF...exposure to VOC also increased plasma histamine levels...

these results indicate that sMCS patients may suffer from ongoing neurogenic inflammation which is aggravated by VOC..." 

 25 controls, MCS, and allergy subjects (total 75) before and after exposure to a painted room.

Substance P (SP), Vasoactive Intestinal Peptide (VIP), Nerve Growth Factor (NGF), and Histamine (H).

For SP Controls 38 before 39 after. MCS 105 before 153 after. Allergy 75 before 74 after.
For VIP Controls 10 before 11 after. MCS 43 before 68 after. Allergy 22 before 21 after.
For NGF Controls 148 before 156 after. MCS 1129 before 1696 after. Allergy 550 before 560 after.
For H Controls 260 before 260 after. MCS 271 before 534 after. Allergy 550 before 560 after.

The control and allergy group are nearly unchanged after exposure to paint (VOC).

MCS people have elevated markers before exposure to paint which can be attributed to the defective airway epithelium and ambient combustion aerosol.
  

References

 

KIMATA, H. EFFECT OF EXPOSURE TO VOLATILE ORGANIC COMPOUNDS ON PLASMA LEVELS OF NEUROPEPTIDES, NERVE GROWTH FACTOR, AND HISTAMINE IN PATIENTS WITH SELF REPORTED MULTIPLE CHEMICAL SENSITIVITY. INT JRNL OF HYG AND ENV H 207:2;159-63 2004

MEGGS W.J. HYPOTHESIS FOR INDUCTION AND PROPAGATION OF CHEMICAL SENSITIVITY BASED ON BIOPSY STUDIES EHP 105:2; 473-78 1997