MCS 8 Airway Origin: Reactive, Measurable, and Releasing Systemically

[michael edward badolato jr]

When MCS people were exposed to capsaicin -  cough occurred 5 times (5 coughs) at a concentration  .150  far less than both the control group  1.120  and the chronic cough group .630.

NOGAMI H. ET AL. CAPSAICIN PROVOCATION TEST AS A DIAGNOSTIC METHOD FOR DETERMINING MULTIPLE CHEMICAL SENSITIVITY. ALLERGOLOGY INT 2: 153-57 2004:  

"...The findings of the present study indicate that the mechanisms underlying MCS may originate in the sensory nervous system..."

MILLQVIST E. ET AL. CHANGES IN LEVELS OF NERVE GROWTH FACTOR IN NASAL SECRETIONS AFTER CAPSAICIN  INHALATION  IN PATIENTS WITH AIRWAY SYMPTOMS FROM SCENTS AND CHEMICALS. ENV H PERS 113;7: 844-52 2005: 

"...after capsaicin provocation the patients showed a significant increase in NGF which was related to capsaicin cough sensitivity...SHR (sensory hypereactivity) is real and measurable, demonstrating a pathophysiology in the airways of these patients compared to healthy subjects...

 

OORTGIESEN ET AL. RESIDUAL OIL FLY ASH AND CHARGED POLYMERS ACTIVATE EPITHELIAL CELLS AND NOCICEPTIVE SENSORY NEURONS. AM J PHYSIOL LUNG CELL MOL PHYSIOL. 278: L683-95 2000: 

"...The data show that both epithelial cells which are the first to encounter xenobiotics, and sensory neurons in which the terminals may be directly exposed under pathophysiological conditions, are activated by ROFA (residual oil fly ash). Their differential sensitivities and cell to cell interaction will affect the onset and persistence of symptoms of PM - related airway disorders in both healthy individuals and those with pre-existing pathological conditions...these cellular effects may initiate and sustain the symptoms of inflammation and hyperesponsiveness associated with PM..." 

MOHANKUMAR S.M.J. PARTICULATE MATTER, OXIDATIVE STRESS, AND NEUROTOXICITY. NEUROTOX 29: 479-88 2008: 

"...acute CAPs (concentrated air particles from an urban community) exposure stimulate increases in cytokine levels in the nasal passages (Reichelman et al 2004)...after multiple exposure, the inflammatory cytokines may have enough time to enter systemic circulation and become detectable...it is known that sub-chronic PM exposure produces pulmonary inflammation which results in systemic cytokine levels (Ruckerl et al 2007)...PM exposure is associated with pulmonary inflammation and the release of inflammatory cytokines and mediators from respiratory epithelia into the systemic circulation..."

 

The airway epithelial cell population and its sensory innervation - genetically predisposed and subsequently altered in a continuous environment of combustion byproduct fine particle aerosol - release mediators of inflammation including cytokines resulting in a cascade of multi-organ events including dysfunction of detox systems (Deluca 2010).

  

References 

DELUCA C. ET AL BIOLOGICAL DEFINITION OF MULTIPLE CHEMICAL SENSITIVITY FROM REDOX STATE AND CYTOKINE PROFILING AND NOT FROM POLYMORPHISMS OF XENOBIOTIC-METABOLIZING ENZYMES TOX AND APPLIED PHARM 248;285-92 2010

MILLQVIST E. ET AL. CHANGES IN LEVELS OF NERVE GROWTH FACTOR IN NASAL SECRETIONS AFTER CAPSAICIN  INHALATION  IN PATIENTS WITH AIRWAY SYMPTOMS FROM SCENTS AND CHEMICALS. ENV H PERS 113;7: 844-52 2005

MOHANKUMAR S.M.J. PARTICULATE MATTER, OXIDATIVE STRESS, AND NEUROTOXICITY. NEUROTOX 29: 479-88 2008

NOGAMI H. ET AL. CAPSAICIN PROVOCATION TEST AS A DIAGNOSTIC METHOD FOR DETERMINING MULTIPLE CHEMICAL SENSITIVITY. ALLERGOLOGY INT 2: 153-57 2004

OORTGIESEN ET AL. RESIDUAL OIL FLY ASH AND CHARGED POLYMERS ACTIVATE EPITHELIAL CELLS AND NOCICEPTIVE SENSORY NEURONS. AM J PHYSIOL LUNG CELL MOL PHYSIOL. 278: L683-95 2000

RUCKERL R. ET AL. AIR POLLUTION AND INFLAMMATION (INTERLEUKIN 6, C-REACTIVE PROTEIN, FIBRINOGEN) IN MYOCARDIAL INFARCTION SURVIVORS) ENV H P 115;7:1072-80 2007