Multiple Chemical Sensitivity Etiology
Airway Genetics and Ambient Combustion Aerosol
References for MCS ab, ac, and ae are combined to refs below af.
References
Afrah A. et al. Spinal substance P release in vivo during the induction of long-term potentiation in dorsal horn neurons. Pain 96:49-55 2002
Agopyan N et al. Negatively charged 2 and 10 micron particles activate vanilloid receptors, increase cAMP, and induce cytokine release. Tox and Appl Pharm 186(2): 63-76 2003
Amara N. et al. Diesel exhaust particles induce matrix-metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 293;1:L170-81 20077
Andre E. et al. Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 118:2574-82 2008
Azkue J. et al. Induction of long-term potentiation of C fibre-evoked spinal field potentials requires recruitment of group I, but not group II/III metabotropic glutamate receptors. Pain 106:373-79 2003
Baeza-Squiban A. et al. Diesel exhaust particles increase NFkB DNA binding activity and c-fos proto-oncogene expression in human bronchial epithelial cells. Tox In Vitro 13 817-22 1999
Bains J. & Shaw C. Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res Rev 25:335-58 1997
Bandell M. et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41:849-57 2004
Bang S. et al. Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation . Eur J Neurosc 26:2516-23 2007
Bascom et al. Neurogenic inflammation: with additional discussion of central and perceptual integration of non-neurogenic inflammation. EHP 105(2):531-7 1997
Baulig A. et al. Role of Paris PM2.5 components in the pro-inflammatory response induced in airway epithelial cells. Tox 261: 126-35 2009.
Baulig A. et al. Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells.Am J Physiol. Lung Cell mol Physiol 285 L671-679 2003a
Bautista D. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124: 1269-82 2006
Bayram H. et al. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am J Resp Cell Mol Biol 18:441-48 1998
Bedard A. and Parent A. Evidence of newly generated neurons in the human olfactory bulb. Dev Brain Res 151: 159-68 2004
Bell I. et al. Neural sensitization model for multiple chemical sensitivity: overview of theory and empirical evidence. Tox Ind H. 15:295-304 1999
Bell I. et al. Quantitative EEG patterns during nose versus mouth inhalation of filtered room air in young adults witha nd without self-reported chemical odor intolerances. Int J Psychophys iol 28:23-5 1998
Bell I. Clinically relevant EEG studies and psychophysiological findings: possible neural mechanisms for multiple chemical sensitivity. Toxicol 111:101-17 1996
Berg N.D. et al. Genetic susceptibility factors for multiple chemical sensitivity revisited. Int J Hyg Env H 213: 131-39 2010.
Bessac B. & Jordt S. Breathtaking TRP channels : TRPA1 and TRPV1 in airway chemosensation and reflex control. Phys 23:360-70 2008
Bessac B. et al. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin invest 118:1899-1910 2008a
Bessac B. et al. TRPA1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J 23;4:1102-14 2009
Blau J. & Solomon F. Smell and other sensory disturbances in migraine. J Neurol 232:275-76 1985
Boland S. et al. Mechanisms of GSM-CSF release by diesel exhaust particles in human airway epithelial cells. Am J Phys 278: L25-32 2000
Boland S. et al. Diesel exhaust particles are taken up by human airway epithelial cells in vitro and after cytokine production. Am J Phys 276: L604-13 1999
Bolt H.M. & Their R. Relevance of the deletion polymorphisms of the glutathione-s-transferases GSTT1 and GSTM1 in pharmacology and toxicology. Curr Drug Metab 7:613-28 2006
Bolton J. et al. Role of quinones in toxicology. Chem Res Tox 13:135-60 2000
Bonvallot V. et al. Organic compounds from diesel exhaust particles elicit a pro-inflammatory response in human airway epithelial cells and induce cytochrome P450 1A1 expression. Am J Resp Cell Mol Biol 25: 515-21 2001
Bonvallot V. et al. Activation of transcription factors by diesel exhaust particles in human bronchial epithelial cells in vitro. Inhal Tox 12:359-64 2000
Brone B. et al. Tear gases CN, CR, and CS are potent activators of the human TRPA1 receptor. Tox Appl Pharm 231: 150-6 2008
Burtscher H. et al. Characterization of particles in combustion engine exhaust J Aerosol Sci 29:389-96 1998
Burtscher H. and Schmidt-Ott A. In situ measurement of adsorption and condensation of polyaromatic hydrocarbons on ultrafine c particles by means of photoemission. J Aerosol Sci 17:699-703
Caceres A. et al. A sensory neuronal ion channel essential for airway inflammation and hypereactivity in asthma. PNAS 106;22:9099-9104 2009
Cadle S.H et al. Composition of light duty motor vehicle particulat... in the Denver, Colorado area. Env Sc Tech 33;14: 2328-39 1999
Calderon-Garciduenas L. et al. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulationof amyloid beta-42 and alpha-synuclein in children and young adults. Tox Pathol 36: 289-310 2008
Calderon-Garciduenas L. et al. Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution. Tox Pathol 32: 650-58 2004
Calderon-Garciduenas L. et al. Air pollution and brain damage. Tox Pathol 30: 373-89 2002
Calderon-Garciduenas L. et al. Respiratory tract pathology and cytokine imbalance in clinically healthy children chronically and sequentially exposed to air pollutants. Med hyp 55(5): 373-78 2000
Calderon-Garciduenas L., Maronpot R.R. et al. DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration. Tox Pathol 31: 524-38 2003
Calderon-Garciduenas L., Mora-Tiscareno A. et al. Respiratory damage in children exposed to urban pollution. Pediatr Pulmonal 36: 148-61 2003
Calderon-Garciduenas L. et al. Respiratory tract pathology and cytokine imbalance in clinically healthy children chronically and sequentially exposed to air pollutants. Med Hyp 55(5): 373-378 2000
Canning P. et al. Endogenous neurokinins facilitate synaptic transmission in guinea pig airway parasympathetic ganglia. Am J Physiol Regul Integr Comp Physiol 283:R320-30 2002
Carr M. & Undem B. Bronchopulmonary afferent nerves. Respirology 8:291-301 2003
Chung H. et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 8:18-30 2009
Christopoulos A. & El-Fakahany E. The generation of nitric oxide by G protein-coupled receptors. Life Sc 64;1:1-15 1999
Conant K. et al. Matrix-metalloproteinase-1 interacts with neuronal integrins and stimulates dephosphorylation of Akt. J Biol Chem 279(9):8056-62 2004
Dai Y. et al. Sensitization of TRPA1 by PAR 2 contributes to the sensation of inflammatory pain. J Clin Invest 117:1979-87 2007
Damann N. et al. Chemosensory properties of murine nasal and cutaneous trigeminal neurons identified by viral tracing. BMC Neurosc 7:46 2006
Dalle-Donne I. et al. Biomarkers of oxidative damage in human disease. Clin Chem 52:601-23 2006
Datla K.P. Short term supplementation with plant extracts rich in flavonoids protect nigrostriated dopaminergic neurons in a rat model of Parkinsons disease. Am Coll Nutr 26;4:341-49 2007
Davis K. et al. Novel effects of nitric oxide. Ann Rev Pharmacol Toxicol 41:203-36 2001
Deluca C. et al. Biological definition of multiple chemical sensiti... from redox state and cytokine profiling and not from polymorphisms of xenobiotic metabolizing enzymes. Tox and Appl Pharm 248: 285-92 2010
Deluca C. et al. The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. Int J Env Res Pub H 8: 2770-97 2011.
Derjean D. et al. Dynamic balance of metabotropic inputs causes dorsal horn neurons to switch functional states. Nat Neurosc 6:274-81 2003
Dhaka A. et al. TRP ion channels and temperature sensation. Ann Rev Neurosc 29:135-61 2006
Dinh Q. et al. Expression of substance P and vanilloid receptor (VR1) in trigeminal sensory neurons projecting to the mouse nasal mucosa. Neuropeptides 37:245-50 2003
Ding J. & Weinberg R. Localization of soluble guanylyl cyclase in the superficial dorsal horn. J Comp Neurol 495:668-78 2006
Dinis P. Anandamide-evoked activation of vanilloid receptor I contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. J Neurosc 24:11253-263 2004
Elder A. et al. Translocation of inhaled ultrafine manganese oxide particles in the central nervous system. EHP 114:1172-78 2006
Escalera J. et al. TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J Biol Chem 283:24136-44 2008
Finger T. & Bottger B. Peripheral peptidergic fibers of the trigeminal nerve in the olfactory bulb of the rat. J Comp Neurol 1;334(1):117-24 1993
Fisher-Wellman K.H. and Bloomer R.J. Exacerbated postprandial oxida...
stress induced by the acute intake of a lipid meal compared to isoenergetically administered carbohydrate, protein, and mixed meals in healthy young men. Am Coll Nutr 29;4:373-81 2010
Friedman D. & De ver Dye T. Migraine and the environment. Headache 49: 941-52 2009
Fung J. et al. Cytochrome P4501A1 in rat peripheral blood lymphocytes: inducibility in vivo and bioactivation of benzo[a]pyrene in the Salmonella typhimurium mutagenicity assay in vitro. Mutat Res 438:1-12 1999
Gauriau C. & Bernard J. Pain pathways and parabrachial circuits in the rat. Exp Physiol 87:251-58 2002
Gavett S.H. et al. Capsaicin receptor antagonist and c-fiber depletion reduce pulmonary responses to particulate matter in BALB/c mice. The Toxicologists 18:405 1998
Gerde P. et al. The rapid alveolar absorption of diesel-soot adsorbed benzo[a]pyrene: bioavailability, metabolism, and dosimetry of an inhaled particle-borne carcinogen. Carcinogenesis 22;5:741-49 2001
Gerde P. et al. Benzo{a}pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium. Carcinogenesis 18:1825-32 1997
Gerde P. et al. Particle-associated polycyclic aromatic hydrocarbons - a reappraisal of their possible role in pulmonary carcinogenesis. Toxical Appl Pharmacol 108:1-13 1991
Ghelfi E. et al. Cardiac oxidative stress and electro-physiological changes in rats exposed to concentrated ambient particles are mediated by TRP-dependent pulmonary reflexes. Tox Sc 102;2:328-36 2008
Goldstone J. et al. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol 300:366-84 2006
Halliwell B. & Cross C. Oxygen derived species: their relation to human disease and environmental stress. EHP 102 (Suppl 10):5-12 1994
Harmsen A. et al. The role of macrophages in particle translocation from lungs to lymph nodes. Sci 230:1277-80 1985
Haxhiu M. et al. Involvement of glutamate in transmission of afferent constrictive inputs from the airways to the nucleus tractus solitarius in ferrets. J Autonom Nerv Sys 80:22-30 2000
Hayes J. et al. Glutathione transferases. Ann Rev Pharm Tox 45:51-88 2005
Hayes A. et al. Effects of neonatal administration of capsaicin on nociceptive thresholds in the mouse and rat. J Pharm Pharmacol 33;3:183-85 1981
Hazari M. et al. TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmia in hypertensive rats exposed to diesel exhaust. EHP 119:951-57 2011
Hazari M. et al. A single exposure to particulate or gaseous air pollution increases the risk of aconitine-induced cardiac arrhymthias in hypertensive rats. Tox Sc 112(2):532-42 2009
Helke C. & Hill K. Immunohistochemical study of neuropeptides in vagal and glossopharyngeal afferent neurons in the rat. Neurosc 26:539-51 1988
Hinman A. et al.TRP channel activation by reversible covalent modification. Proc Nat Acad Sc USA 103:19564-568 2006
Holroyd K. et al. Genetic modeling of susceptibility to nitrogen dioxide-induced lung injury in mice. Am J Physiol 273;1-3:L595-602
Ichinose T. et al. Murine strain differences in allergic airway inflammation and immunoglobulin production by a combination of antigen and diesel exhaust particles. Tox 122;3:183-92 1997
Inoue K-i. et al. Effects of nanoparticles on antigen-related airway inflammation in mice. Resp Res 6:106 2005
Inoue T. & Bryant B. Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons. Pain 117:193-203 2005
Irlbacher K. & Meyer B. Nasally triggered headache. Neurology 58:294 2002
Jordt S. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260-65 2004
Jung C.G. Psychological Types. Princeton University Press and in the Portable Jung Viking Press 1921
Kelman I. The triggers or precipitants of the acute migraine attack. Cephalagia 27:394-402 2007
Khasabov S. Spinal neurons that possess the substance P receptor are required for the development of central sensitization. J Neurosc 22:9086-98 2002
Khatsenko O. et al. Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. Proc N Acad Sc USA 90:11147-51 1993
Kimata H. Effect of exposure to volatile organic compounds on plasma levels of neuropeptides, nerve growth factor, and histamine in patients with self reported multiple chemical sensitivity. Int J Hyg Env H 207:2 159-63 2004.
Kittelson D.B. Engines and nanoparticles: a review. J Aerosol Sci 29: 575-88 1998
Kleeberger S. Genetic susceptibility to ozone exposure. Tox Lett 82-83:295-300 1995
Kleeman M.J. et al. Size and composition distribution of fine particle matter emitted from woodburning, meat charbroiling, and cigarettes. Env Sc Tech 33;20: 3516-23 1999
Kumagai Y. et al. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome reductase and involvement of the bioactivation in the DNA damage. Free Rad Biol Med 222:479-87 1997
Kumagai Y. et al. Apparent inhibition of superoxide dismutase activity in vitro by diesel exhaust particles. Free Rad Biol Med 18:365-71 1995
Kummer W. Ultrastructure of calcitonin gene-related peptide-immunoreactive nerve fibers in guinea-pig peribronchial ganglia. Regul Pept 37:135-42 1992
Kunkler P. et al. TRPA1 receptors mediate environmental irritant-induced meningeal vasodilitation. Pain 152;1:38-44 2011
Kwan K. et al. TRPA1 contributes to cold, mechanical, and chemical nociception but it is not essential for hair-cell transduction. Neuron 50:277-289 2006
LaMotte R. et al. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. J Physiol 448: 749-764 1992
Latremoliere A. & Woolf C. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10;9:895-926 2009
Lefebvre C. et al. Evidence that DHPG-induced nociception depends on glutamate release from primary afferent c-fibres. Neuroreport 11:1631-35 2000
Lewis J. et al. Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice. Neurotox 26: 113-23 2005
Li J. et al. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. EHO 119: 784-93 2011
Li J. et al. Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS. EHP 117:400-09 2009
Li N. et al. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. J Immunol 165: 3393-3401 2000
Lucchini R.G. et al. Neurological impacts from inhalation of pollutants and the nose-brain connection. Neurotox (2011) doi:10.1016/j.neuro.2011.12.001 in press
Lundborg M. et al. Ability of rabbit alveolar macrphages to dissolve metals. Exp Lung Res 7:11-22 1984
Macpherson L. et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541-45 2007
Mantyh P. et al. Inhibition of hyperalgesia by ablation of lamina I spinal neurones expressing the substance P receptor. Science 278:275-79 1997
Matsui Y. et al. Tracking the pathway of diesel exhaust particles from the nose to the brain by x-ray florescense analysis. Spectrochimica Acta Part B 64: 796-801 2009
Mayer M. et al. Voltage dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309:261-63 1984
Mazzone S. & Geraghty D. Respiratory actions of tachykinins in the nucleus of the solitary tract. Characterization of receptors using selective agonists and antagonists. Br J Pharmacol 129:1121-31 2000
McDonald D. et al. Neurogenic inflammation in the rat trachea. II. Identity and distribution of nerves mediating the increase in vascular permeability. J Neurocytol 17:605-28 1988
McNamara C. et al. TRPA1 mediates formalin-induced pain. Proc Nat Acad Sc USA 104:31525-30 2007
Meggs W.J. Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies. Env H Perspect 105(2): 473-78 1997
Meggs W.J. et al. Nasal pathology and ultrastructure in patients with chronic airway inflammation (RADS and RUDS) following an irritant exposure. J Tox Clin Tox 34;4: 383 1996
Meggs W.J. and Cleveland Jr. C.H. Rhinolaryngoscopic examination of patients with multiple chemical sensitivity syndrome. Arch Env H 48: 1-14 1993
Merck Manual of Diagnosis and Therapy 17th Ed. Drug Input and Disposition; Metabolism. Chapter 298: pg 2563 Merck Research Laboratories 1999
Miyabara Y. et al. Murine strain differences in airway inflammation caused by diesel exhaust particles. Eur Resp J 11: 291-98 1998
Miyabara Y. et al. Diesel exhaust enhances allergic airway inflamma... and hyperesponsiveness in mice. Am J Resp Crit Care Med 157: 1138-44 1998a
Mohankumar S.M.J. et al. Particulate matter, oxidative stress and neurotoxicity. Neurotox 29: 479-88 2008
Molliere M.et al. Metabolism of benzo[a]pyrene in the combined rat liver-lung perfusion system. Tox 45:143-54 1987
Moncada S. et al. XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol Rev 49:137-42 1997
Moncada S. et al. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-42 1991
Myers A. et al. Anatomical and electrophysical comparison of the sensory innervation of bronchial and tracheal parasympathetic ganglion neurons. J Autonom Nerv Sys 61:162-68 1996
Nassenstein C. et al. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 586;6:1595-604 2008
Nassini R. et al. The 'headache tree' via umbellone and TRPA1 activates the trigeminovascular system. Brain doi:10 1093/brain/awr272 2011
Natusch D.F.S. and Tomkins P.A. Theoretical consideration of the adsorption of polynuclear aromatic hydrocarbon vapor onto fly ash in a coal-fired power plant. In Jones P.W. and Freudenthal R.I. (eds) Polynuclear Aromatic Hydrocarbons, Ravan Press, New York, NY 3:145-53 1978
Nielsen G.D. Mechanisms of activationof the sensory irritant receptor by airborne chemicals. Crit Rev Tox 21;3:183-208 1991
Nel A.E. et al. The role of particulate pollutants in pulmonary inflammation and asthma:evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med 7: 20-26 2001.
Neumann S. et al. Inflammatory pain sensitivity mediated by phenotypic switch in myelinated primary sensory neurons. Nat 384:360-4 1996
Nielsen G.D. Mechanisms of activation of the sensory irritant receptor by airborne chemicals. Crit Rev Tox 21:3:183-208 1991
Nyberg K. et al. Estimation of PH in individual alveolar macrophage phagolysosomes. Exp Lung Res 15:499-510 1989
Obata K. et al. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest 115:2393-2401 2005
Oortgiesen et al. Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. Am J Physiol Lung Cell Mol Physiol 278: L683-95 2000
Orriols R. et al. Brain Dysfunction in Multiple Chemical Sensitivity. J Neurol Sc 287: 72-78 2009
Ottaviani F. Centro-peripheral etiopathogenesis of primary headache triggered nasally. Ital J Neurol Sci 16:35-9 1995
Pakkanen T.A. et al. Size distributions of mass and chemical compon... in street-level and rooftop PM1 particles in Helsinki. Atmosph Env 37: 1673-90 2003
Pereira W. Chlorination studies AM. II. The reaction of aqueous hypochlorous acid with alpha-amino acids and dipeptides. Biochem Biophys Acta 313:170-80 1973
Prior M. et al. Capsaicin pretreatment modifies hydrogen sulphide-induced pulmonary injury in rats. Tox Pathol 18;2:279-88 1990
Rinder J. et al. Capsaicin-, resiniferatoxin-, and lactic acid-evoked vascular effects in the pig nasal mucosa in vivo with reference to characterization of the vanilloid receptor. Pharm Tox 78:327-35 1996
Roy et al. Susceptibility to pollutant-induced airway inflammation is neurogenically mediated. EPA EIMS Metadata report 59754 2000
Salmon P. et al. Cognitive abilities mediated by frontal-subcortical circuits. Chapter 5 in: Lichter D.G. & Cummings J.L. editors. Frontal-subcortical circuits in psychiatric and neurological disorders. New York: The Guilford Press: 114-50 2001
Satoh H. et al. Inhibitory effects of capsazepine and SR 48968 on citric acid-induced bronchoconstriction in guinea-pigs. Eur J Pharm 236;3:367-72 1993
Scheerens H. et al. The involvement of sensory neuropeptides in toluene diisocyanate-induced tracheal hyperreactivity in the mouse airways. Br J Pharm 119;8:1665-71 1996
Segura-Valdez L. et al. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest 117(3):684-94 2000
Shafer F. & Buettner G. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free rad Biol Med 30:1191-1212 2001
Society of Automotive Engineers. Schematic of diesel particles and vapor phase compounds. SAE Paper no. 940233 1994
Soliman A. et al. mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical sensitivity. Neuropharm 48:325-32 2005
South S. et al. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosc 23:5031-40 2003
Steerenberg P.A. et al. Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro. Exp Lung Res 24: 85-100 1998
Stone V. et al. The role of oxidative stressin the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Tox in vitro 12:649-59 1998
Symanowicz P. et al. Lack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57B1/6J mouse. Neurosc Lett 362:150-3 2004
Taylor-Clark T. & Undem B. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol 588;3:423-33 2010
Thomas R. et al. ETS1, NFkB and AP-1 synergistically transactivate the human GM-CSF promoter. Oncogene 14:Z845-55 1997
Thompson C.L et al. Relationships among benzo[a]pyrene metabolism benzo[a]pyrene-dial-epoxide DNA adduct formation and sister chromatid exchanges in human lymphocytes from smokers and nonsmokers. Cancer Res 49:6501-11 1989
Ulrich-Lai Y. Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from rat trigeminal ganglion: evidence for intraganglionic neurotransmission. Pain 91:219-26 2001
Veronesi B. & Oortgiesen M. The TRPV1 receptor: target of toxicants and therapeutics. Tox Sc 89(1):1-3 2006
Veronesi B. et al. Effects of subchronic exposure to concentrated ambient particles VII Degeneration of dopaminergic neurons in APO E-1 mice. Inhal Tox 17; 4-5: 235-41 2005
Veronesi B. et al. Electrostatic charge activates inflammatory vanilloid (VR1) receptors. Neurotox 24: 463-73 2003
Veronesi B. et al. The surface charge of visible particulate matter predicts biological activation in human bronchial epithelial cells. Tox and Appl Pharm 178: 144-54 2002a
Veronesi B. et al. Particulate matter inflammation and receptor sensitivity are target cell specific. Inhal Tox 14(2): 159-83 2002b
Veronesi B. and Oortgiesen M. Neurogenic inflammation and particulate matter (PM) air pollutants. Neurotox 22: 795-810 2001
Veronesi B. et al. Vanilloid capsaicin receptors influence inflammatory sensitivity in response to particulate matter. Tox Appl Pharm 15;169(1): 66-76 2000
Veronesi B. et al. Particulate matter initiates inflammatory cytoki... by activation of capsaicin and acid receptors in a human bronchial epithelial cell line. Tox and Appl Pharm 154: 106-15 1999a
Veronesi B.et al. Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. Neuropep 33;6: 447-56 1999b
Willis W. et al. Long-term potentiation in spinalthalamic neurons. Brain Res Rev 40:202-14 2002
Woolf C. Central sensitization: uncovering the relation between pain and plasticity. Anesthes 106:864-7 2007
Woolf C. & Salter M. Neuronal plasticity: increasing the gain in pain. Science 288:1765-69 2000
Woolf C. et al. Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain. Philos Trans R Soc Land B Biol Sc 351:441-48 1996
Woolf C. & Thompson S. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: Implications for the treatment of post-injury pain hypersensitivity states. Pain 44:293-99 1991
Woolf C. et al. Substance P and calcitonin gene-related peptide modulate the gain of the nociceptor flexor withdrawal reflex in the rat. Neurosc Lett 66:226-30 1986
Yang Y. et al. Endothelial glutathione-s-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-kappa B translocation. Tox Appl Pharm 230:187-96 2008
Yeadon M. et al. Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharm 5;1:39-50 1992
Yeh H.C. et al. Comparisons of calculated respiratory tract deposition of particles based on the proposed NCRP model and the new ICRP66 MODEL. Aer Sci Tech 25:134-40 1996
Young M. et al. Behavioral and electrophysiologicalevidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord. Brain Res 777:161-69 1997
Young M. et al. Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons. Neuropharm 33:141-44 1994
Zhang L. Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice. Exp Lung Res 21;4:503-18 1995
Zhu G. et al. Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. Hum Mol Gen 18(11):2053-62 2009
Ziedinski H. et al. Modeling the interactions of particulates with epithelial lining fluid antioxidants. Am J Phys 277:L719-26 1999
Tags:
Views: 27
© 2024 Created by michael edward badolato jr. Powered by