MCS, Nutrition,Top Article Index (aba)

[michael edward badolato jr]

Nutrition Index: Fwd I-V, Pref, Consensus III, IV Points 15-38

type 2 diabetes: 16,17,20,22                                    Top Articles MCS

unsaturated fats: fwd III,19                                        Abebe 2002: 8,app VI

urinary loss: calcium 34,35,37b,c                             Baldwin 1998: 7, 14j

urinary stones: 37c                                                    Baulig 2003a: 1,14d

UV (ultraviolet): 36                                                     Bascom 1992: 2,9e,14f,h,i

vegetable oil drink: 15                                               Bartha 1999: 9a,b,c

vegetable oils: 17                                                       Bell 1998,1996: 14i,j

vegetables: fwd I,V,27,31,37b                                    Belpomme 2015: 2,7,14i       

vegigram: 31, max fwd V                                           Berg 2010: 3,14n,o

villi, villus flattening: 26, 33                                        Bessac 2008: 9d,14i

viscous soluble fiber: fwd V,26                 Block 2012: 3,14d; Block 2011: 3,14p

vitamins and minerals: fwd II,V,27,30,31;                 Block 2008: 5,6,14d,m,t

      supplementation 34,36,37d,e                               Block 2004: 14m

vitamin A: fwd I,V,27,31                                              Bonham 2001: 2,14h

vitamin B1 (thiamine): fwd I,II,27,30                          Bonvallot 2001: 1,14d

vitamin B2: fwd I,V,27,31              Calderon-Garciduenas 2008: 5,6,14d,i,j,L,m,r

vitamin B6: fwd I,II,27,30                                           Castranova 2002: 2,9e,14h,j

vitamin B12: fwd I,III,23,24,30                                    Daniell 1997: 14j

vitamin C: detail 29; and GST deletion                     Dantoft 2015: 7

      24; distribution fwd I,V,27,31                               Dantoft 2014: 1,2,14e,h,k,L

vitamin D: detail 36; 35,36,37d                                  Deering-Rice 2011: 9d,14d

vitamin E: fwd I,V,27,31                                    Deluca 2010: 1-3,7,14e,m,n,o,p,s

vitamin K: fwd I,V,27,31                                        Doty 2008: 5; Doty 1994: 2,14h

walking: 20,34 water: 20                            Elberling 2007: 2; Elder 2006: 7,14d,i

wave reflections: pref                                                  Emch 2000: 14j

weight bearing exercise: 20,33,34,37,38                   Gentner 2009: 4,14d        

wheat (whole): fwd II,pref,24,25                                 Gerde 2001: 1,14d

whole grain: fwd I,II,V,pref,22,27,30                           Gillespie 2013: 6

yellowfin tuna: fwd III,23                                             Hahn 1997: 14j

zinc: fwd I,II,27,30,34                                                   Haraiwa 2013: 7,14k

                                                                                       Hazari 2011: 7,9d,14d

Top Articles Nutrition                                             Hogg 2009: 2,14k

Aeberli 2011: 22 fructose lipogenesis                        Holst 2011: 1,2,14h,i,s

Bolland 2011: 34 calcium                                            Irigaray 2018a: 8,app VI

Dawson-Hughes 2008: 33 acid base                          Jordt 2011: 2,14h

Drewnowski 2000: 32 glucosinolates                        Jung 1921: 3,14a,c,n

DRI 2006: 20,27,28,34-36 nutrients                             Kimata 2004: 2,9g,14e,h,s

Farquhar 2015: 35 sodium                                Latremoliere 2009: 1,2,4,9d,14h,i

Heaney 2008: 36 vitamin D                                        Lee and Pisarri 2001: 2,14h

Hurrell 2010: 23 iron absorption                                Lewis 2005: 4,14d

Kavanagh 2013: 22 MT & liver damage               Lucchini 2012: 1,14d

McGough 2005: 25 celiac disease                             Maes 2012: 7,14k,L,m

Ramon 2009: 23 mercury in fish                                Matsui 2009: 4,14d

Remer 2003: 33 acid base                                         Meggs 1997: 2,4,14d,f,g,i,r

Rodriguez-Garcia 2019: 23, 37i phytoestrogens      Milqvist 2005: 2,4,14h,s

Rousseau 2004: 29 vitamin C                                     Nakatomi 2014: 14m

Sekhar 2011: 24 amino acids                                      Nassini 2011: 2,9d,14h

Stephens 2011: 24 muscle carnitine                          Nogami 2004: 2,4,14h

     transport capacity                                    Orriols 2009: 2,4,7,14i,s,app II,III,IV

Vakur Bor 2010: 24 vitamin B12                                 Sakai 2004: app II, III

                                                                                       Tran 2013: 1,2,14h,i,s

                                                               Veronesi 2001: 3,9d,14a,b,d,f,i,n,r,app VI

Postscript and Appendix Splash located within - for the most part not included in the index - are expanded detail and application of content presented in the 38 point Consensus.

Appendix: Added Splash I-VI

    I.   Safdar 2011: To Run or Not to Run

    II.  MCS 2ab Etiology: Nasal Cytokines in Context

    III. MCS 3ac: Belpomme 2020, Lull 2010 - Ambient PM and Reactive Microgliosis

    IV. MCS 2ac Etiology: Belpomme 2015 - Formula or Reality?

    V.  MCS 3ad: MCS Genetics - Likely a Neural Portrait

    VI. MCS 3ae Treatments Unsafe? Fermented Papaya (FPP) and Ginkgo Biloba

Important Caution:                              

Seeing a doctor is sometimes essential - but often life threatening. Do not take medical advice unless fully understanding and in agreement. Make it your decision. Medications - a leading cause of death - are extremely overused in the United States. Improving lifestyle is preferred - most conditions result from a touch of genetics combined with diet/exercise habits (SJF, LE) - and an ambient combustion aerosol (ACA) promoting insidious neurodegeneration.

Study this book carefully - details and overall context matter - rereading as necessary. You want to learn and be intentional about your health. Taking good care is our responsibility. 

AUSTRALIAN REVIEW 2010:
"...the majority of respondents could not identify any original cause of their condition. Less than one fifth indicated a "chemical" or "pesticide" exposure as responsible for their hypersensitivity...(Caress 2003)...
...a more recent Canadian survey also revealed a female predominance amongst MCS subjects with the greatest percentage of MCS cases occurring at 45-64 years of age...(Park and Knudson 2007)..."

CANADIAN REVIEW 2007:

"...approximately 60-80% of people diagnosed with environmental sensitivities in various surveys are female (Caress 2004, 2003, 2002) Gibson 2003, Joffres 2001, McKeown-Eyssen 2001, 2000)...

...the prevalence of environmental sensitivities increases with age. For example, the prevalence of unexplained physical symptoms (chronic fatigue, fibromyalgia, and multiple chemical sensitivity) in Canadians increases with age from 1.6% of people aged 12 to 24 years to 6.9% in people 45 to 64 years old (Park 2007). In a Statistics Canada survey of Canadian nurses, 1.4% of nurses younger than 35 years reported chemical sensitivities, which increased to 3.7% in nurses 35-44 years old, and 4.3% and 4.8% in successive decades (Statistics Canada 2005). Similarly, in studies in Arizona, 15% of college students and 37% of elderly participants reported heightened sensitivity to chemicals (Caress 2004, Bell 1993)..."

Phase I and II Detox Enzymes Defined:

MERCK 1999:

Phase I reactions form a new or modified functional group or a cleavage (oxidation, reduction, hydrolysis). These are non synthetic - the most important are cytochrome P450 isoenzymes (CYPs) that transfer electrons and catalyze oxidation.

Phase II reactions are synthetic - involving conjugation with an endogenous compound forming metabolites more polar and readily excreted by the kidneys and liver in urine and bile. 

BLOCK 2012:
"...The epithelium of olfactory mucosa has high activity and expression of cytochrome P450 (CYP) isoforms including CYP1A2, 2A, 2B, 2E, and 2G (Longo 2000, Livertoux 1996, Voight 1993). These phase I enzymes catalyze the biotransformation of ambient air pollutants such as polycyclic aromatic hydrocarbons, semi-quinones and quinones into toxic metabolites, such as mutagenic epoxide or reactive oxygen species...

...phase II enzymes in the nasal cavity epithelium, such as UFP-glucuronosyltransferase, epoxide hydrolase, sulfotransferases, and glutathione-S-transferases (Bond 1988), function to detoxify the reactive metabolites formed by CYP dependent activities. Thus, the appropriate balance of phase I and II enzymes in the epithelium of olfactory mucosa may provide a first line of defence for the brain, limiting axonal transport of ambient air pollutants and toxic metabolites from the olfactory nerve cells to the olfactory bulb..."

Sensory receptor activation and alveolar macrophage involvement in damaged airway epithelium due to ACA PM - changes in the innate inflammatory immune system (Hogg 2009, Abbas 2007) - result in release of mediators - neuropeptides, cytokines, chemokines, and growth factors (Dantoft 2014, Maes 2012, Deering-Rice 2011, Hazari 2011, Costa 2010, Deluca 2010, Taylor-Clark 2010, Caceres 2009, Anand 2008, Bessac 2008, Nassenstein 2008, Bautista 2006, Inoue 2005, Kobayashi 2005, Veronesi 2001), increase in circulating leukocytes, production of acute phase proteins (Hiraiwa 2014, 2013, Hogg 2009, Goto 2004, Mukae 2001), nitric oxide overproduction (Maes 2012, Deluca 2010, Calderon-Garciduenas 2008), and dysfunction of Phase I and II xenobiotic and antioxidant enzymes in a systemic condition of severe oxidative stress (Deluca 2010, Liptrott 2009, Oslund 2008, Chun 2002, Sterner-Kock 1999, Tinel 1999, Tanabe 1996, Tapner 1996, Nadin 1995, Stadler 1994, Khatsenko 1993).

Tailpipe and Chimney Emissions: Horizontal Coning

Emission plume modeling has been applied to power plants. Effective stack height is the actual plus upward motion of pollution due to heat. Several plume shapes are possible - principle are neutral coning and inversion limited mixing.

Neutral cone is achieved most afternoons - horizontal with the wind - approx equal projection of pollutants down and upward - atmosphere cooler with height. Inversion limited mixing occurs most frequently evenings through midmorning - upward movement is flattened by warm air over cold at 600-1500 feet.

Effective stack height of tailpipe and residential chimney emission is a very short distance upward before horizontally projecting a continuous ground level concentration - acute symptoms or masking all the time.