Multiple Chemical Sensitivity Etiology
Airway Genetics and Ambient Combustion Aerosol
Griffith O.W. Biological and pharmalogical regulation of mammalian glutathione synthesis. Free Rad Biol Med 27;9/10:922-35 1999
Griffith O.W. & Mulcahy R.T. The enzymes of glutathione biosynthesis y-glutamylcysteine synthetase. Adv Enzymol Relat Areas Mol Biol 73:209-67 1999
Grimble R.F. et al. Cysteine and glycine supplementation modulate the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet. J Nutr 122:2066-73 1992
Guerrerio A.L. et al. Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. AJCN 95:892-900 2012
Guyton A.C. & Hall J.E. Textbook of Medical Physiology 10th ed. Saunders Co. p 512-688 2000
Guyton and Hall 12th Ed https://doctorlib.info/physiology/textbook-medical-physiology/36.html
Hahn M. & Bonkovsky HL. Multiple chemical sensitivity syndrome and porphyria. A note of caution and concern. Arch Int Med 157(3): 281-5 1997
Haley R.W. et al. Association of low pon1 type Q (type A) arylesterase activity with neurologic symptom complexes in Gulf War Veterans. Tox Appl Pharm 157:227-33 1999
Harmsen A. et al. The role of macrophages in particle translocation from lungs to lymph nodes. Sci 230:1277-80 1985
Haverkate F et al. Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Lancet.34;9050:462-6 1997
Hawkes C.H. et al. Parkinson's disease: a dual hit hypothesis. Neuropathol Appl Neurobiol 33:599-614 2007
Hawkes C. Olfaction in neurodegenerative disorders. Mov Dis 18:364-72 2003
Hayes J.D. et al. Glutathione Transferases. Ann Rev Pharm Tox 45:51-88 2005
Hayes J.D. & Pulford D.J. The glutathione s-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30:445-600 1995
Hayes A. et al. Effects of neonatal administration of capsaicin on nociceptive thresholds in the mouse and rat. J Pharm Pharmacol 33;3:183-85 1981
Hazari M. et al. TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmia in hypertensive rats exposed to diesel exhaust. EHP 119:951-57 2011
Heinrichy J. & Assman G. Fibrinogen and cardiovascular risk. J Cardiovasc Risk 2;3:197-205 1995
Hellerstein M.K. Mitigating factors and metabolic mechanisms in fructose-induced nonalcoholic fatty liver disease: the next challenge. AJCN 96:251-2 2012
Henriksson J. et al. Uptake of nickel into the brain via olfactory neurons in rats. Tox let 91:153-62 1997
Herrmann W. and Obeid R. Causes and early diagnosis of vitamin B-12 deficiency. Dtsch Arztebl Int 150;40:680-5 2008
Hickey W.F. Basic principles of immunological surveillance of the normal central nervous system. Glia 36:118-24 200
Hinman A. et al.TRP channel activation by reversible covalent modification. Proc Nat Acad Sc USA 103:19564-568 2006
Hiraiwa K. & vanEeden S.F. Nature and consequences of the systemic inflammatory response induced by lung inflammation. Provisional Chapter. Intech 2014
Hiraiwa K. & vanEeden S.F. Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollution. Hindawa Med Inflam 2013:ID#619523
Hirtz D. et al. How common are the “common” neurologic disorders? Neurology 68:326–337 2007
Hogg J.C. & vanEeden S.F. Pulmonary and systemic response to atmospheric pollution. Resp 14:336-46 2009
Holroyd K. et al. Genetic modeling of susceptibility to nitrogen dioxide-induced lung injury in mice. Am J Physiol 273;1-3:L595-602 1997
Holst H. et al. Increased capsaicin-induced secondary hyperalgesia in patients with multiple chemical sensitivity. Clin J Pain 2:156-62 2011
Huang L. et al. Vasoactive intestinal peptide enhances TNF-alpha-induced IL-6 and IL-8 synthesis in human proximal renal tubular epithelial cells by NF-kB-dependent mechanism. Inflam 35;3:1154-60 2012
Ichinose T. et al. Murine strain differences in allergic airway inflammation and immunoglobulin production by a combination of antigen and diesel exhaust particles. Tox 122;3:183-92 1997
Inoue K-i. et al. Effects of nanoparticles on antigen-related airway inflammation in mice. Resp Res 6:106 2005
Irigaray P. et al. Oxidative stress in electrohypersensitivity self reporting patients: Results of a prospective in vivo investigation with comprehensive molecular analysis. Int J Mol Med 42:1885-98 2018a
Irigaray P. et al. Beneficial effects of a Fermented Papaya Prepara... for the treatment of electrohypersensitivity self-reporting patients: results of a phase I-II clinical trial with special reference to cerebral pulsation measurement and oxidative stress analysis. Func Foods Health Dis 8(2):122-44 2018b
Jackson A. et al. Synthesis of erythrocyte glutathione consuming safe amount of dietary protein. Am J Cl Nutr 80:101-7 2004
Jahoor F. et al. Protein deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation. J Nutr 125:1462-72 1995
Jang H.M. et al. Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc Natl Acad Sci USA 106:14063-8 2009
Jansen J.H. et al. Interleukin 6 is a permissive factor for monocyte colony formation by human hematopoietic progenitor cells. J Exp Med 175:1151-54 1992
Jellinger K.A. Neuropathological spectrum of synucleopathies. Mov Disord 18:52-12 2003
Joffres M.R. et al. Environmental sensitivities: prevalence of major symptoms in a referral center: the Nova Scotia Environmental Sensitivities Research Center Study. EHP 109:161-165 2001
Jordt S. Trigeminal TRPs and the scent of pain. Pain 152;1: 4-5 2011
Jordt S. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260-65 2004
Jung C.G. Psychological Types. Princeton University Press and in the Portable Jung Viking Press 1921
Kaplan G.G. et al. Effect of ambient air pollution on the incidence of appendicitis. CMAJ 181(9) 2009
Kappelman M.D. et al. Direct health care costs of Crohn's disease and ulcerative colitis in US children and adults. Gastroenterology 135:1907-13 2008
Kelman I. The triggers or precipitants of the acute migraine attack. Cephalagia 27:394-402 2007
Kennedy G. et al. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Rad Biol & Med 39:584-89 2005.
Kenney J.S. et al. Synthesis of interleukin-1 alpha, interleukin-6, and interleukin-8 by cultured human nasal epithelial cells. J Aller Clin Immun 93:1060-67 1994
Khatsenko O. et al. Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. Proc N Acad Sc USA 90:11147-51 1993
Kim W.G. et al. Regional difference in susceptibility to lipopolysaccaride-induced neurotoxicity in the rat brain: role of microglia. J Neurosc 20:6309-16 2000
Kimata H. Effect of exposure to volatile organic compounds on plasma levels of neuropeptides, nerve growth factor, and histamine in patients with self reported multiple chemical sensitivity. Int J Hyg Env H 207:2 159-63 2004.
Kittelson D.B. Engines and nanoparticles: a review. J Aerosol Sci 29: 575-88 1998
Kleeberger S. Genetic susceptibility to ozone exposure. Tox Lett 82-83:295-300 1995
Kleeman M.J. et al. Size and composition distribution of fine particle matter emitted from woodburning, meat charbroiling, and cigarettes. Env Sc Tech 33;20: 3516-23 1999
Klein-Platat C. et al. Plasma FA concentration is associated with the metabolic syndrome and low grade inflammation in overweight adolescents. Am J CL Nutr 82:1178-84 2005
Kobayashi K. et al. Distinct expression of TRPM8,TRPA1, and TRPV1 in rat primary afferent neurons with adelta/c fibers and colocalization with trk receptors. J Comp Neur 493:596-606 2005
Koloski N.A. et al. Hygeine hypothesis in inflammatory bowel disease: a critical review of the literature. World J Gastroenterol 14:165-73 2008
Kreutzer R. et al. Prevalence of people reporting sensitivities to chemicals in a population-based survey. Am J Epidem 150:1-12 1999
Kreyling W.G. et al. Ultrafine particle-lung interactions: does size matter? J Aer Med 19;1:74-83 2006
Kreyling W.G. et al. Dosimetry and toxicology of ultrafine particles. J Aer Med 17;2:140-52 2004
Kumagai Y. et al. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome reductase and involvement of the bioactivation in the DNA damage. Free Rad Biol Med 222:479-87 1997
Kumagai Y. et al. Apparent inhibition of superoxide dismutase activity in vitro by diesel exhaust particles. Free Rad Biol Med 18:365-71 1995
Kunkler P. et al. TRPA1 receptors mediate environmental irritant-induced meningeal vasodilitation. Pain 152;1:38-44 2011
Lakatos P.L. Environmental factors affecting inflammatory bowel disease: have we made progress? Dog Dis 27:215-25 2009
Latremoliere A. & Woolf C. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10;9:895-926 2009
Le J & Vilcek J. Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab. Invest 56: 234–48 1987
Lewis J. et al. Trigeminal uptake and clearance of inhaled magnesium chloride in rats and mice. Neurotox 26:113-23 2005
Li J. et al. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. EHO 119:784-93 2011
Li J. et al. Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS. EHP 117:400-09 2009
Li N. et al. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. J Immunol 165: 3393-3401 2000
Liptrott N.J. et al. The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. Br J Pharm 156:497-508 2009
Livertoux M.H. et al. The superoxide production mediated by the redox cycling of xenobiotics in rat brain microsomes is dependent on their reduction potential. Brain res 725:207-16 1996
Loeffler D.A. et al. Effect of enhanced striatal dopamine turnover in vivo on glutathione oxidation. Clin Neuropharm 17:370-79 1994
Loftus E.V. Jr. et al. Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gut 46:336-43 2000
Loftus E.V. Jr. et al. Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gastroenterology 114:1161-68 1998
Long T.C. et al. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Env Sc Tech 40;14:4346-52 2006
Longo V. et al. Effect of starvation and chlormethiazole on cytochrome P450s of rat nasal mucosa. Biochem Pharm 59:1425-32 2000
Lorusso L. et al. Immunological aspects of chronic fatigue syndrome. Autoimmune Rev 8;4:287-91 2009
Lossinsky A.S. & Shivers R.R. Structural pathways for macromolecular and cellular transport across the blood brain barrier during inflammatory conditions. Rev Histol Histopath 19:535-64 2004
Lucchini R.G. et al. Neurological impacts from inhalation of pollutants and the nose-brain connection. Neurotox (2011) doi:10.1016/j.neuro.2011.12.001 in press
Lukacs N.W. Chemokines and their receptors in chronic pulmonary disease. Curr Drug Targ Inflam Aller 4:313-7 2004
Lull M. & Block M. Microglial activation and chronic neurodegeneration, J Amer Soc Exper Neurother 7:354-65 2010
Lundborg M. et al. Ability of rabbit alveolar macrophages to dissolve metals. Exp Lung Res 7:11-22 1984
Lu S.C. Regulation of glutathione synthesis. Mol Asp Med 30;1-2:42-59 2009
Lyons J. et al. Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet. Proc Natl Acad Sc USA 97:5071-6 2000
Ma J.Y. & Ma J.K. The dual effect of the particulate and organic components of diesel exhaust particles on the alteration of pulmonary immune/inflammatory responses and metabolic enzymes. J Env Sc Health Part C Env Carcinog Ecotox Rev 20:117-47 2002
Macpherson L. et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541-45 2007
Maes M. et al. Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): increased interleukin -1, tumor necrosis factor-alpha, PMN elastase, lysozyme and neopterin. J Aff Dis 136: 933-39 2012
Maes M.and Twisk F.N. Chronic fatigue syndrome: Harvey and Wessely's (bio) psychosocial model versus a bio (psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. BMC Med 8;35 2010
Maes M. & Twisk F.N. Why myalgic encephalomyelitis/chronic fati... Neuro Endocrinol Lett. 30(6):677-93 2009
Maes M. et al. Not in the mind of neurasthenic lazybones but in the cell nucleus: patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta.Neuroendocrin Let 28;4:456-62 2007a
Maes M. et al. Not in the mind but in the cell: increased production of cyclooxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuroendocrin Let 28;4:463-69 2007b
Manfredi S. et al. Glutathione s-transferase T1 and M1-null genotypes and coronary artery disease risk in patients with Type 2 diabetes mellitus. Pharmacogenomics 10:29-34 2009
Materazzi S. et al. Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain 154: 2750-58 2013
Matsui Y. et al. Tracking the pathway of diesel exhaust particles from the nose to the brain by x-ray florescense analysis. Spectrochimica Acta Part B 64: 796-801 2009
McKeown-Eyssen G.E. et al. Multiple chemical sensitivity: discriminant validity of case definitions. Arch Env H 56:406-412 2001
McKeown-Eyssen G.E. et al. Reproducibility of the University of Toronto self-administered questionnaire used to assess environmental sensitivity. Am J Epid 51:1216-1222 2000
McNamara C. et al. TRPA1 mediates formalin-induced pain. Proc Nat Acad Sc USA 104:31525-30 2007
MCS 15 Etiology: Airway Genetics
Meggs W.J. Arch Env H 54(5) 309-11 1999
Meggs W.J. Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies. Env H Perspect 105(2): 473-78 1997
Meggs W.J. et al. Nasal pathology and ultrastructure in patients with chronic airway inflammation (RADS and RUDS) following an irritant exposure. J Tox Clin Tox 34;4: 383 1996
Meggs W.J. Neurogenic Inflammation and sensitivity to environmental chemicals. EHP 101;3:234-38 1993
Meggs W.J. and Cleveland Jr. C.H. Rhinolaryngoscopic examination of patients with multiple chemical sensitivity syndrome. Arch Env H 48: 1-14 1993a
Merck Manual of Diagnosis and Therapy 1999
Miller K.A. et al., “Long-term exposure to air pollution and incidence of cardiovascular events in women,” New Eng J Med 356;5:447-58 2007
Milqvist E. et al. Changes in level of nerve growth factor in nasal secretions after capsaicin inhalation in patients with airway symptoms from scents and chemicals. EHP 113;7: 844-52 2005
Minty A. et al. Interleukin 13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362: 248-50 1993
Miyabara Y. et al. Murine strain differences in airway inflammation caused by diesel exhaust particles. Eur Resp J 11: 291-98 1998
Miyabara Y. et al. Diesel exhaust enhances allergic airway inflamma... and hyperesponsiveness in mice. Am J Resp Crit Care Med 157: 1138-44 1998a
Mohankumar S.M.J. et al. Particulate matter, oxidative stress and neurotoxicity. Neurotox 29: 479-88 2008
Molliere M.et al. Metabolism of benzo[a]pyrene in the combined rat liver-lung perfusion system. Tox 45:143-54 1987
Muchmore H.G. et al. Neutropenia in healthy men at the South Polar Plateau.
Arch. Intern. Med.125: 646–8 1970
Muhlfeld C, et al. Interactions of nanoparticles with pulmonary structures and cellular responses. Am J Physiol Lung Cell Mol Physiol 294:L817–829 2008
Mukae H. et al. The effect of repeated exposure to particulate air pollution (PM-10) on the bone marrow. Am J Resp Crit Care Med 163:201-9 2001
Mullol J. et al. Vasoactive intestinal peptide (VIP) induces IL-6 and IL-8, but not G-CSF and GM-CSF release from a human bronchial epithelial cell line. Neuropep 31;2:119-24 1997
Murphy P. et al. Induction of interleukin-6 in axotomized sensory neurons. J Neurotox 15;2-7:5130-38 1995
Mutlu E.A. et al. Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. Part Fibre Tox 8:19 2011
Mutter J. et al. Comments on the article "The Toxicology of Mercury and its Chemical Compounds" by Clarkson and Magos (2006). Crit Rev Tox 37:537-49 2007
Myronuck O.J. Augmented ingestion of carbon monoxide and sulfur oxides by occupants of vehicles while idling in drive-up facility lines. Water, Air, Soil Poll 7;2:203-13 1977
Nadin L. et al. Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis alpha. Gastroenterology 109:198-205 1995
Nakatomi Y. et al. Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: A 11C-(R)-PK11195 PET Study. Journal of Nuclear Medicine 55(6): 945-50 Pubmed 24665088, 2014
Nassenstein C. et al. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 586;6:1595-604 2008
Nassini R. et al. The 'headache tree' via umbellone and TRPA1 activates the trigeminovascular system. Brain doi:10 1093/brain/awr272 2011
Natusch D.F.S. and Tomkins P.A. Theoretical consideration of the adsorption of polynuclear aromatic hydrocarbon vapor onto fly ash in a coal-fired power plant. In Jones P.W. and Freudenthal R.I. (eds) Polynuclear Aromatic Hydrocarbons, Ravan Press, New York, NY 3:145-53 1978
Nel A. Atmosphere air pollution-related illness: effects of particles. Sc 308:804-6 2005
Nemmar A. et al. Passage of inhaled particles into the blood circulation in humans, Circ 105;4:411–414, 2002.
Nemmar A.et al. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster,” Am J Resp Crit Care Med 164;9:1665–1668 2001.
Nguyen M.D. et al. Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosc 3:216-27 2002
Nielsen G.D. Mechanisms of activation of the sensory irritant receptor by airborne chemicals. Crit Rev Tox 21:3:183-208 1991
Nilius B. et al. Transient receptor potential cation channels in disease. Physiol Rev 87:166-217 2007
Nogami H. et al. Capsaicin provocation test as a diagnostic method for determining multiple chemical sensitivity. Allergology Int 2: 153-57 2004
Nordin Fredrickson G. et al. Plasma oxidized LDL: a predictor for acute myocardial infarction. Intern Med 253;4:425-29 2003
Nyberg K. et al. Estimation of PH in individual alveolar macrophage phagolysosomes. Exp Lung Res 15:499-510 1989
Oberdorster G. et al. Extrapulmonary translocation of ultrafine particles following whole-body inhalation exposure of rats. J Tox Env H 65:1531-43
Oberdorster G. et al. Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhaled particles. Inhal Tox 8(s);73-89 1996
Oikonen M. et al. Ambient air quality and occurrence of multiple sclerosis relapse. Neuroepid 22:95-9 2003
Oortgiesen et al. Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. Am J Physiol Lung Cell Mol Physiol 278: L683-95 2000
Orriols R. et al. Brain Dysfunction in Multiple Chemical Sensitivity. J Neurol Sc 287: 72-78 2009
OSHA: Partial list of chemicals in diesel exhaust. 2012
Oslund K. et al. Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. AmJ Respir Cell Mol Biol 39:279-88 2008
Pahl H.L. Activators and target genes of Rel/NF-Kappa B transcription factors. Oncogene 18:6853-66 1999
Pakkenberg B. et al. The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J Neurol Neurosurg Psch 54:30-33 1991
Pan W. & Kastin A.J. Upregulation of the transport system for TNF-alpha at the blood-brain barrier. Arch Phys Biochem 109:350-53 2001
Parham P. et al. The immune system. 3rd ed. Garland Science, Taylor & France group, LLC 2009
Park J.& Knudson S. Medically unexplained physical symptoms. Health Reports 18:43-47. Statistics Canada, Catalogue 82-003 2007
Patchen M.L. et al. Administration of interleukin-6 stimulates multilineage hematopoiesis and accelerates recovery from radiation-induced hematopoietic depression. Blood 177:472-80 1991
Pedata P. et al. Ultrafine particles and effects on the body: a review of the literature. G Ital Med Lav Ergon 32;1:23-31 2010
Pervin T. et al. Societal Costs of air pollution-related health hazards; A review of methods and results. Cost Ef Res Alloc 6:19 2008
Peters A et al. Translocation and potential neurological effects of fine and ultrafine particles a critical update. Part Fibre Toxicol 3:13. 2006
Phalen R.F.& Mendez L.B. Dosimetry considerations for animal aerosol inhalation studies. Biomarkers 14(s1):63-6 2009
Piacentini S. et al. GSTT1 and GSTM1 gene polymorphisms in European and African populations. Mol Biol Rep 38:1225-30 2011
Pigatto P.O. et al. Allergological and toxicological aspects in a Multiple Chemical Sensitivity cohort. Ox Med Cell Long ID#356235 2013
Pope III C.A et al. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease, Circulation 109;1:71–77 2004.
Prior M. et al. Capsaicin pretreatment modifies hydrogen sulphide-induced pulmonary injury in rats. Tox Pathol 18;2:279-88 1990
Punnonen J. et al. Interleukin 13 induces interleukin 4-interdependent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 90:3730-34 1993
Ridker PM et al. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation.98;8:731-3 1998
Ridker PM et al. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med.336;14:973-9 1997
Rivest S. How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis. Pychoneuroendocrin 26:761-88 2001
Rogers A.D. and LaffoleyD.d'A. International earth system expert workshop on ocean stresses and impacts. Oxford 18pp 2011. International Programme on the State of the Ocean.org
Rothen-Rutishauser B, et al. A newly developed in vitro model of the human epithelial airway barrier to study the toxic potential of nanoparticles. Altex 25:191–196 2008
Rothen-Rutishauser B.M. Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Env Sc Tech 40: 4353-59 2006
Rothwell N.J. & Luheshi G.N. Interleukin-1 in the brain: biology, pathology and therapeutic target. Trends Neurosc 23:618-25 2000
Roy et al. Susceptibility to pollutant-induced airway inflammation is neurogenically mediated. EPA EIMS Metadata report 59754 2000
Ruckerl R et al. Air pollution and inflammation (interleukin 6, C-reactive protein, fibrinogen) in myocardial infarction survivors. EHP 115;7:1072-80 2007
Sakai M. et al. Effect of relocating to areas of reduced atmospheric particulate matter levels on the human leukocyte count. J Appl Phys 97:1774-80 2004
Salmon P. et al. Cognitive abilities mediated by frontal-subcortical circuits. Chapter 5 in: Lichter D.G. & Cummings J.L. editors. Frontal-subcortical circuits in psychiatric and neurological disorders. New York: The Guilford Press: 114-50 2001
Sama P. et al. The cellular and genomic response of an immortalized microglia cell line (BV2) to concentrated ambient particulate matter. Inhal Toxicol 19;13:1079-87 2007
Sametz W. et al. Vascular effects of isoprostanes after endothelial damage. Prostaglandins Leukot Essent Fatty Acids 61;6:369-72 1999
Satoh H. et al. Inhibitory effects of capsazepine and SR 48968 on citric acid-induced bronchoconstriction in guinea-pigs. Eur J Pharm 236;3:367-72 1993
Schauer J. et al. Measurement of emissions from air pollution sources. 5. C1-C32 organic compounds from gasoline-powered motor vehicles. Env Sc Tech 36:1169-80 2002
Schauer J. et al. Measurement of emissions from air pollution sources. 3. C1-C29 organic compounds from fireplace combustion of wood. Env Sc Tech 35:1716-28 2001
Schauer J. et al. Measurement of emissions from air pollution sources 2. C1 through C30 organic compounds from medium duty diesel trucks. Env Sc Tech 33:1578-87 1999
Schmid O. et al. Dosimetry and toxicology of inhaled ultrafine particles. Biomarkers 14(s1): 67-73 2009
Schnakenberg E. et al. A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes. Env H 6:6 2007
Schwartz J. Short term fluctuations in air pollution and hospital admissions of the elderly for respiratory disease, Thorax 50; 5:531–538 1995.
Sekhar R.V. et al. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Cl Nutr 94:847-53 2011
Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 298:789-91 2002
Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81:741-66 2001
Shi Q. et al. Arterial endothelial dysfunction in baboons fed a high cholesterol high fat diet. Am J Cl Nutr 82:751-9 2005
Siguad S. et al. Air pollution particles diminish bacterial clearance in the primal lungs of mice. Toxical Appl Pharmacol 223:1-9 2007
Sirivelu M.P. et al. Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease/ EHP 114;6:870-4 2006
Society of Automotive Engineers. Schematic of diesel particles and vapor phase compounds. SAE Paper no. 940233 1994
Stadler J. et al. Inhibition of cytochromes P4501A1 by nitric oxide. Proc Natl Acad Sci USA 91:3559-63 1994
Statistics Canada. Findings from the 2005 national survey of the work and health of nurses. 2006
Steerenberg P.A. et al. Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro. Exp Lung Res 24: 85-100 1998
Sterner-Kock A. et al. Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils. J Leukoc Biol 65:1834-40 1999
Stolzel M.et al. Daily mortality and particulate matter in different size classes in Erfurt, Germany. J Exposure Sc Env Epid17;5:458–467 2007.
Stone V. et al. The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Tox in vitro 12:649-59 1998
Sunderland E. Mercury exposure from domestic and imported estuarine and marine fish in the US seafood market. EHP 115(2):235-42 2007
Sunyer J. The neurological effects of air pollutionin children. Eur Resp J 32;3:535-7 2008
Suwa T. et al. Interleukin-6 changes deformability of neutrophils and induces their sequestration in the lung. Am J Resp Crit Care Med 163:070-76 2001
Suwa T. et al. Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow. Am J Physiol Heart Circ Phyiol 279:H2954-60 2000
Symanowicz P. et al. Lack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57B1/6J mouse. Neurosc Lett 362:150-3 2004
Tanabe T. et al. Intracellular signaling pathway of substance P-induced superoxide production in human neutrophils. Eur J Pharmacol 299:187-95 1996
Tapner M. et al. Interferon gamma down-regulates cytochrome P450 3A genes in primary cultures of well-differentiated rat hepatocytes. Hepatology 24:367-73 1996
Taylor-Clark T. & Undem B. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol 588;3:423-33 2010
Terlecky S. et al. Peroxisomes and Aging. Biochim Biophys Acta 1763;12:1749-54 2006
Thia K.T. et al. An update on the epidemiology of inflammatory bowel disease in Asia. Am J Gastroenterol 103:3167-82 2008
Thomas B. & Beal M.F. Parkinson’s disease. Hum Mol Genet 16(2):R183–194 2007
Thomas R. et al. ETS1, NFkB and AP-1 synergistically transactivate the human GM-CSF promoter. Oncogene 14:Z845-55 1997
Thompson C.L et al. Relationships among benzo[a]pyrene metabolism benzo[a]pyrene-dial-epoxide DNA adduct formation and sister chromatid exchanges in human lymphocytes from smokers and nonsmokers. Cancer Res 49:6501-11 1989
Tinel M. et al. Interleukin 2 overexpresses c-myc and down regulates cytochrome P-450 in rat hepatocytes. J Pharm Exp Ther 289:649-55 1999
Todd A.J. Neuronal circuitry for pain processing in the dorsal horn. Natl Rev Neurosc 11(12):823-36 2010
Torres J.L. & Ridker P.M. Clinical use of high sensitivity c-reactive protein for the prediction of adverse cardiovascular events. Curr Opin Cardiol 18;6:471-8 2003
Tracy R.P. et al. Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project. Arterioscler Thromb Vasc Biol. 1997 Jun;17;6:1121-7 1997
Tran et al. Multiple chemical sensitivity: on the scent of central sensitization. Int J Hyg Ind H 216(2):202-10 2013
US DOT FHA Addendum to the 1997 Federal Highway Cost Allocation Study. Final report. May 2000
Uyama N. et al. Neural connections between the hypothalamus and the liver. Anat Rec A Disc Mol Cell Evol Biol 280;808-20 2004
Valavanidis A. et al. Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidatve damaage and carcinogenic mechanisms. J Env Sc H C Env Carc Exotox Rev 26;4:339-62 2008
Veronesi B. & Oortgiesen M. The TRPV1 receptor: target of toxicants and therapeutics. Tox Sc 89(1):1-3 2006
Veronesi B. et al. Effects of subchronic exposure to concentrated ambient particles VII Degeneration of dopaminergic neurons in APO E-1 mice. Inhal Tox 17; 4-5: 235-41 2005
Veronesi B. et al. Electrostatic charge activates inflammatory vanilloid (VR1) receptors. Neurotox 24: 463-73 2003
Veronesi B. et al. The surface charge of visible particulate matter predicts biological activation in human bronchial epithelial cells. Tox and Appl Pharm 178: 144-54 2002a
Veronesi B. et al. Particulate matter inflammation and receptor sensitivity are target cell specific. Inhal Tox 14(2): 159-83 2002b
Veronesi B. and Oortgiesen M. Neurogenic inflammation and particulate matter (PM) air pollutants. Neurotox 22: 795-810 2001
Veronesi B. et al. Vanilloid capsaicin receptors influence inflammatory sensitivity in response to particulate matter. Tox Appl Pharm 15;169(1): 66-76 2000
Veronesi B. et al. Particulate matter initiates inflammatory cytoki... by activation of capsaicin and acid receptors in a human bronchial epithelial cell line. Tox and Appl Pharm 154: 106-15 1999a
Veronesi B.et al. Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. Neuropep 33;6: 447-56 1999b
Voigt J.M. et al. Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa. J Hystochem Cytochem 41:877-85 1993
Wake K. et al. Cell biology and kinetics of Kuppfer cells in the liver. Int Rev Cytol 118:173-229 1989
Wang J. et al. Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO(2) nanoparticles. Tox 254:82-90 2008
Wang J. et al. Transport of intranasally instilled fine Fe203 particles into the brain: micro-distribution, chemical states, and histopathological observation. Biol Trace Elem Res 118:233-43 2007
Weiss ST et al. Relation of FEV1 and peripheral blood leukocyte count to total mortality. The Normative Aging Study. Am. J. Epidemiol.S3;142:493–8 1995
White A.T. et al. Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome. Psychophys 47:615-24 2010
Wimo A et al. An estimate of the worldwide prevalence and direct costs of dementia in 2003. Dement Geriatr Cogn Disord 21:175–181 2006
World Almanac 2011: International Data Base, International Programs Center, US Census Bureau, US Dept of Commerce and the World Factbook, Central Intelligence Agency
Wu G. et al. Glutathione metabolism and its implications for health. J Nutr 134:489-92 2004
Xiao G. et al. Alternative pathways of NF-kB activation: A double-edged sword in health and disease. Cytokine Growth Factor Rev 17:281-93 2006
Yang Y. et al. Endothelial glutathione-s-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-kappa B translocation. Tox Appl Pharm 230:187-96 2008
Yeadon M. et al. Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharm 5;1:39-50 1992
Yeh H.C. et al. Comparisons of calculated respiratory tract deposition of particles based on the proposed NCRP model and the new ICRP66 MODEL. Aer Sci Tech 25:134-40 1996
Zanchi A.C. et al. Chronic nasal instillation of residual-oil fly ash (ROFA) induces brain lipid peroxidation and behavioral changes in rats. Inhal Tox 20;9:795-800 2008
Zhang L. Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice. Exp Lung Res 21;4:503-18 1995
Zhu G. et al. Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. Hum Mol Gen 18(11):2053-62 2009
Ziedinski H. et al. Modeling the interactions of particulates with epithelial lining fluid antioxidants. Am J Phys 277:L719-26 1999
Tags:
Views: 13
© 2025 Created by michael edward badolato jr. Powered by