Multiple Chemical Sensitivity Etiology
Airway Genetics and Ambient Combustion Aerosol
N-6 and N-3
N-6 18-2 linoleic and N-3 18-3 linolenic are the dietary essential fatty acids (EFA) - losses noted in MCS patients (Deluca 2010). N-6 can be formed into arachidonic acid. N-3 serves as precursor for synthesis of the Omega 3 fatty acids - eicosapentaenoic (EPA) and docosohexaenoic DHA (DRI 2006).
Because N-6 and N-3 are found in vegetable oils traditionally used in preparation of foods - deficiency is uncommon. However, more often there is either an excess of N-6 enriching lipoproteins and cell membranes creating a pro-oxidant state, or a disproportion beyond the recommended ratio between 5 and 10 to 1 N-6/N-3. Competing for the same desaturase enzymes - too high a ratio may inhibit N-3 synthesis to DHA while too low may limit desaturation of N-6 to arachidonic (DRI 2006).
Adequate N-3 and formation of Omega 3 EPA and DHA is associated with prevention of arrhythmias, reducing atherosclerosis, decrease in platelet aggregation and plasma triacylglycerol concentration, a slight increase in HDL, modulation of endothelial function, and decreasing inflammatory eicosanoids (DRI 2006).
Excessive intake of preformed Omega 3 EPA and DHA - such as supplements - may result in prolonged bleeding time (DRI 2006).
Among added oils - flaxseed is approx , canola , and soybean 34% of the total composition N-6 and 50, 10, and 5% N-3 respectively. Safflower, corn, peanut, and olive oil - while containing 75, 57, 31, and 8% N-6, have little N-3 (USDA 2014, DRI 2006).
Dietary emphasis on whole grain such as brown rice provides a safe level of N-6 and some N-3, cruciferous vegetables bring more N-3 to the right ratio. Most other vegetables - except dried beans and spinach - contain little N-3. The inclusion of fish adds preformed Omega 3 (USDA 2014, DRI 2006).
Adequate intake is estimated 8-16 grams N-6 and 1-1.6 grams N-3, less than 1/2 ounce and a few drops - within the ratio of 5 and 10 to 1 N-6/N-3 - quantity and proportion contained in the whole foods mentioned above.
Knowing is not enough - we must do.
Each stage of learning is to give up something, even a way of life we have always known.
Care deeply.
Friendly Lifestyle
little use of motorized transportation
thermostat at 50 degrees
modest furnishings
avoid most household and personal care chemicals
use only necessary lighting
avoid unnecessary appliances such as television and dishwashers
don't use pesticides unless absolutely necessary
have mostly bare floors instead of carpets
don't paint unless necessary
avoid particleboard (formaldehyde emitting) furniture, shelving, cabinetry, and paneling
Because N-6 and N-3 are found in vegetable oils traditionally used in preparation of foods - deficiency is uncommon. However, more often there is either an excess of N-6 enriching lipoproteins and cell membranes creating a pro-oxidant state, or a disproportion beyond the recommended ratio between 5 and 10 to 1 N-6/N-3. Competing for the same desaturase enzymes - too high a ratio may inhibit N-3 synthesis to DHA while too low may limit desaturation of N-6 to arachidonic (DRI 2006).
Adequate N-3 and formation of Omega 3 EPA and DHA is associated with prevention of arrhythmias, reducing atherosclerosis, decrease in platelet aggregation and plasma triacylglycerol concentration, a slight increase in HDL, modulation of endothelial function, and decreasing inflammatory eicosanoids (DRI 2006).
Excessive intake of preformed Omega 3 EPA and DHA - such as supplements - may result in prolonged bleeding time (DRI 2006).
Among added oils - flaxseed is approx , canola , and soybean 34% of the total composition N-6 and 50, 10, and 5% N-3 respectively. Safflower, corn, peanut, and olive oil - while containing 75, 57, 31, and 8% N-6, have little N-3 (USDA 2014, DRI 2006).
Dietary emphasis on whole grain such as brown rice provides a safe level of N-6 and some N-3, cruciferous vegetables bring more N-3 to the right ratio. Most other vegetables - except dried beans and spinach - contain little N-3. The inclusion of fish adds preformed Omega 3 (USDA 2014, DRI 2006).
Adequate intake is estimated 8-16 grams N-6 and 1-1.6 grams N-3, less than 1/2 ounce and a few drops - within the ratio of 5 and 10 to 1 N-6/N-3 - quantity and proportion contained in the whole foods mentioned above.
Knowing is not enough - we must do.
Each stage of learning is to give up something, even a way of life we have always known.
Care deeply.
Friendly Lifestyle
little use of motorized transportation
thermostat at 50 degrees
modest furnishings
avoid most household and personal care chemicals
use only necessary lighting
avoid unnecessary appliances such as television and dishwashers
don't use pesticides unless absolutely necessary
have mostly bare floors instead of carpets
don't paint unless necessary
avoid particleboard (formaldehyde emitting) furniture, shelving, cabinetry, and paneling
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