Multiple Chemical Sensitivity Etiology

Airway Genetics and Ambient Combustion Aerosol

Multiple Chemical Sensitivity: 2021 Consensus Criteria 

Baseline, Diagnosis, Patient Rights, Etiology 

Expertise from the most Prestigious Academic, Medical, and Government Research Facilities

Outline; 38 Consensus Points, Added Splash

FWD VegiEnergiNutrigram:

     I.   5 Point Summary

     II.  Energigram                                 

     III. Meat Factor: Fish, Seafood, Meat, Poultry                                            

     IV. Eggs, Dairy                                            

     V.  Vegigram Max                                                                          

Preface: Is It Kind?                    

I.   Baseline GSAA, ACA, SRPE 1-8

II.  Diagnosis, Patient Rights, Etiology 9-14

III. Baseline: Nutrition and Exercise 15-31

     A. SJF, LE 15-20

     B. Whole Food Nutrition 21-31

IV. Baseline: Nutrition and Exercise 32-38

     C. Suboptimal Actors 32

     D. Maintaining Bone Density 33-37

     E. Preventing Atherosclerosis 38

Appendix: Added Splash I-VI

MCS Etiology: CAR References

MCS 2021: CAR Nutrition References

Index: MCS, Nutrition, Top Article

Outline Expanded IIIA,B, IVC,D,E

III. Baseline: Nutrition and Exercise 

     A. SJF, LE 15-20

          15. Impaired Capillary Circulation

          16. Dietary Fat: Cancer 

          17. Cordain 2005

          18. GSAA, ACA, SRPE, SJF, LE

          19. Specified Junk Food (SJF) Defined

          20. Prevention and Reversal

     B. Whole Food Nutrition 21-31

          21. Gram/Calorie Conversion

          22. Fructose Lipogenesis

          23. Hemoglobin: Iron Absorption

          24. Protein: GSH Synthesis

          25. Digestion: Wheat, Rye, Barley

          26. Viscous Fiber: Villus Flattening

          27. Nutrients in Matrix

          28. N-6 and N-3 EFA

          29. Vitamin C: 200-300 mg?

          30. Nutrigram

          31. Vegigram

IV. Baseline: Nutrition and Exercise

     C. Suboptimal Actors 32

     D. Maintaining Bone Density 33-37

          33. Acid Base Balance

          34. Calcium: Adequate Not Excessive

          35. Salt: A Small Amount

          36. Vitamin D: 1000 iu Soft Gel - Safe Upper Limit?

          37. Summary: Bone Health, Postmenopause

     E. Preventing Atherosclerosis 38

Preface: Is It Kind?

Air pollution and specified junk food (SJF) increase daily morbidity and mortality. Improvement and reversal is possible, especially concerning nutrition; ambient combustion aerosol (ACA) more difficult, as shown by decades of  professional journal findings presented in book and on the MCS Etiology website. But it began early, a regular guy, having consumed lots of SJF. Bisquick batter, waffle iron - golden brown - fill in holes with melting butter, powdered sugar, maple syrup - multiple portions; does nutrition matter? Added fat and oil sludges blood components impairing fine capillary circulation for 72 hours.

Bisquick, breakfast cereals, commercial bread, pizza dough - refined wheat dilemma: 7-10% of whole wheat carbohydrate - fiber and digestion resistant starch (RS) - reaches the large intestine having escaped small intestinal enzyme digestion. To reduce bulk - bran and germ are milled out - and caloric density further increased with oil and sweetener. Modern whole wheat (high fiber and RS) contrasts with brown rice digestive comfort - no need milling to white rice or adding empty calories.

SLAVIN 2003"...Whole grains are composed of germ, bran, and endosperm. In contrast, refined grains lack both the germ and bran, which are removed during processing and results in the loss of fiber, vitamins, minerals, lignans, phenolic compounds, and phytochemicals..."

Drug consumption is a great detriment, but will mention here only the two most popular: alcohol involves liver damage, central nervous system depression, and impairment of fine capillary circulation; caffeine is a central nervous system, cerebral, and heart muscle stimulant - as are two other xanthines - theophylline (in tea) and theobromine (cocoa).

Coffee produces systemic inflammation (>200 ml raises IL-6, CRP, SAA, TNF alpha, and WBC) participating in metabolic syndrome: obesity, decreased insulin effectiveness, insulin resistance - impairment of acute glucose management, abnormal coagulation processes, and ischemic heart disease (Moisey 2008Zampelas 2004). Coffee - caffeine partly responsible - raises homocysteine levels associated with increased cardiovascular disease risk (Verhoef 2002). Homocysteine is an independent risk factor for dementia and cognitive impairment without dementia (Haan 2007). Coffee is a risk for low bone mineral density and osteoporosis - caffeine and phosphoric acid (colas) interfere with calcium absorption (Tucker 2006). Polyphenols in black and herb teas, cocoa, and coffee, inhibit zinc and non heme iron absorption (Hurrel 1999Coudray 1998). Caffeinated coffee adversely affects fetal length and skeletal growth (Bakker 2010) and causes aortic stiffness and wave reflections impairing ventricular function and together compromise coronary blood flow, predispose to ischemia, and by increasing pulse pressure - pulsatile stretch the arteries leading to mechanical fatigue of their elastic components. Manifesting as increased systolic pressure, increased pulse pressure (and especially central pulse pressure) and reduced diastolic pressure - aortic stiffness and wave reflections are independent predictors of cardiovascular disease risk. Coffee and black tea cause aortic stiffness and wave reflections - but green tea wave reflections only - maybe due to protection from flavonoids (Viachopoulos 20062005).

Among over 65 without severe hypertension (high blood pressure), the more caffeinated beverages, the less mortality from cardiovascular disease - possibly countering postprandial hypotension (after meal low blood pressure) - however, no protection against cardiovascular disease under 65 and cerebrovascular disease in any age group (Greenberg 2007). Caffeinated beverages - stimulant - may counter some junk food consequences; caffeine cessation best gradual, keeping in mind diet quality.

Ambient Combustion Aerosol (ACA) toxicity, lack of weight-bearing exercise (LE) - drive never walk; birthday ice cream cake teaching moment right/wrong blurred: disease, drugs, disability, nursing home;

Whole wheat excessive fiber and RS replaced by refined grain, sugar, fats/oils; instead of whole grain brown rice and sufficient vegetable intake: resulting inflammation, circulatory impairment, atherosclerosis, interference with glucose metabolism, type 2 diabetes, acidosis, calcium loss, nutrient shortage including vitamins, minerals, and phytoestrogens; osteoporosis, osteoarthritis; unhealthy adipose deposition and digestive substrate - breast, intestinal, prostate cancer;

Expertise without conflict of interest, 8.5 by 11 lay flat coil bound design puts prevention and reversal facts in view. MCS Etiology website has text on forums - studies linked. Consensus Point 30 Nutrigram: 2 vegetable (Cg,K); 30a inside rear cover is 5 veg (Cg, K, Br, C, Bf).  Best wishes, Mike  August 2022 

Bakker R. et al. Maternal caffeine intake from coffee and tea, fetal growth and the risk of adverse birth outcomes: the Generation R Study. AJCN 91:1091-98 2010 

Coudray C. Short-term ingestion of chlorogenic or caffeic acids decreases zinc but not copper absorption in rats, utilization of isotopes and inductively-coupled plasma mass spectrometry technique. BrJN 80;6:571-74 1998

Greenberg J.A. et al. Caffeinated beverage intake and the risk of heart disease mortality in the elderly: a prospective analysis. AJCN 85;2:392-89 2007 

Haan M.N. et al. Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on aging. AJCN 85;2:511-17 2007

Hurrel R.F. et al. Inhibition of non haem iron absorption in man by polyphenolic containing beverages. BrJN 81;4:289-95 1999

Moisey L.L. et al. Caffeinated coffee consumption impairs blood glu... homeostasis in response to high and low glycemic index meals in healthy men. AJCN 87;1251-61 2008 

Slavin J. Why whole grains are protective: biological mechanisms. Proc Nutr Soc 62:129-34 2003

Tucker K.L. et al. Colas but not other carbonated beverages are associated with low bone mineral density in older women: the Framingham Osteoporosis Study. AJCN 84:1932-42 2002

Verhoef P. et al. Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans. AJCN 76:1244-8 2002

Viachipolous C. et al. Acute effect of black and green tea on aortic stiffness and wave reflections. Am Coll Nutr 25;3:216-23 2006

Viachipolous C. et al. Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections. AJCN 81:1307-12 2005

Zampelas et al. Association between coffee consumption and inflammatory markers in healthy persons - the Attica Study. AJCN 80;4:862-7 2004

                             

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