MCS 2ad Etiology: Proof Positive in a Nutshell

[michael edward badolato jr]

MCS 2ad Etiology: Proof Positive in a Nutshell

Before and after 2 hours in a freshly painted room:

Plasma marker Substance P (SP) a chemical neurotransmitter:

25 Control Normal subjects plasma levels 38 and 39 before and after paint

25 MCS 105 and 153 before and after paint - ouch!

25 Allergy 75 and 74  - not great but no further rise on the paint

Plasma marker Vasoactive Intestinal Peptide (VIP) another inflammatory regulator:

25 Control Normal 10 and 11 before and after paint

25 MCS 43 and 68 before and after - ouch!

25 Allergy 22 and 21 - no further rise on the paint

Plasma marker Nerve Growth Factor (NGF) - along with SP and VIP indicate airway nerve primary involvement in MCS:

25 Control Normal 148 and 156 before and after paint

25 MCS 1129 and 1696 before and after - high in the stratosphere!

25 Allergy 889 and 896 - no further rise on the paint

Histamine (H) - inflammatory release in many disease conditions:

25 Control Normal 260 and 260 before and after paint

25 MCS 271 and 534 before and after - released from mast cells, an acutely felt ouch that occurs on new or sudden exposure increase

25 Allergy 550 and 560 - ongoing elevated histamine allergic symptoms but no further rise on the paint

In summary:

1) Allergy Subjects

a) no reaction to paint indicated by plasma markers

b) elevated markers before paint indicate reaction to allergen

2) MCS Subjects

a) react to fresh paint - increased SP, VIP, NGF, and H

b) elevated SP, VIP, and NGF before paint indicate ongoing reaction to toxic chemicals in the general ambient environment. H is normal before exposure to paint - sudden increase of toxic exposure - such as the fresh paint - elevates histamine - giving MCS a sometimes allergic outward appearance.

MCS (multiple chemical sensitivity)

Reference

Kimata H. Effect of exposure to volatile organic compounds on plasma levels of neuropeptides, nerve growth factor, and histamine in patients with self reported multiple chemical sensitivity. Int J Hyg Env H 207:2 159-63 2004.