Multiple Chemical Sensitivity Etiology
Airway Genetics and Ambient Combustion Aerosol
What is MCS and Environmental Illness?
What is MCS and Environmental Illness?
There are environmental and physiological factors common to MCS and other illnesses correctly referred to as environmental - including ME/CFS, Alzheimers, Parkinsons, and COPD - and common genetics (Li 2011, Calderon-Garciduenas 2008, Veronesi 2001, 2000) but individual uniqueness and personal exposure history cause confusion in recognizing the common denominators among these diseases.
The MCS Etiology website emphasizes the important common environmental and physiological factors and is not intended as an explanation for the detail of every individual case. Briefly explained - a principle common factor is barrier feature breakdown of what has been called the innate inflammatory immune system (Hogg 2009, Abbas 2007). The important barrier features include an airway epithelium of intact columnar epithelial cells with tight junction integrity protecting the olfactory and sensory nerves (Calderon-Garciduenas 2001, Meggs 1997) and a blood brain barrier (BBB) which consists of the endothelial lining (inner walls) of the fine capillary blood vessels in the brain (Calderon-Garciduenas 2008, Abbott 2005, Lossinsky 2004).
With barrier damage - exposure of the sensory nerves (peripheral extension of the trigeminal nervous system to the brain) - environmental sensors - neurochemical transmitter release - increases systemic inflammation (Hiraiwa 2013, Hogg 2009, Calderon-Garciduenas 2008, 2003, 2001, Veronesi 2001, Meggs 1997) and the central nervous system (brain) is more penetrated by non-self constituents of the environment via exposed sensory and olfactory neural pathways (Block 2012, Calderon-Garciduenas 2010, 2008, Baulig 2009, 2003a, Genter 2009, Matsui 2009, Elder 2006, Lewis 2005).
MCS, ME/CFS, Alzheimers, Parkinsons, and COPD are all accompanied with damage to barrier features with strong evidence presented by Block 2009 and Calderon-Garciduenas 2008, 2001. There are hundreds if not thousands of supporting articles in the literature. The four pathway summary at the conclusion of Calderon-Garciduenas 2008 should be required reading for everyone - worse than global warming - the increased morbidity and mortality is occurring now - sober acknowledgement of the need for better environment.
Once individuals have acquired damage - defects in the innate inflammatory immune system - regardless of one's subjective impression - a thousand chemicals and metals - much bonded to penetrating fine and ultrafine carbon particle cores (Baulig 2009, 2003a, Bonvallot 2001, 2000, Gerde 2001, Boland 2000, 1999, Baeza-Squiban 1999, Bayram 1998, Kumagai 1997, Thomas 1997) PM 2.5 and UFPM (Gillespie 2013, Pedata 2010, Araujo 2009, Phalen 2009, Schmid 2009, Valavanidis 2008, Calderon-Garciduenas 2008, deHaar 2006, Kreyling 2006, 2004, Donaldson 2003, Oberdorster 1996) - the environment of continuous exhaust and smoke (ambient combustion aerosol [ACA]) - usually largely invisible horizontal coning of tailpipe and chimney emissions - supports disease process because there is so much vulnerability due to increased penetration of damaged epithelial and endothelial barriers (Deering-Rice 2011, Hazari 2011, Costa 2010, Taylor-Clark 2010, Caceres 2009, Anand 2008, Bessac 2008), Nassenstein 2008, Bautista 2006, Inoue 2005, Kobayashi 2005, Veronesi 2001).
ACA health cost is estimated over 100 billion dollars a year in the US.
USDOTFHA 2000:
"...Total social costs of air pollution associated with motor vehicle use are
estimated to range from $30 billion to $349 billion per year (Delucchi 1998). Most of those costs are associated with premature death and illness caused by particulate matter, including both direct particulate emissions and the secondary formation of particulates from other emissions. The wide range of air pollution cost estimates is indicative of the many uncertainties surrounding costs of motor-vehicle-related air pollution..."
"...Moreover, ambient PM, including sulfates, nitrates, and organic aerosols, accounts for about 95% of the total damage cost, and mortality related to ambient PM accounts for about 70% of the total damage cost..."
Breathing exhaust all the time - its horrible - but with individual presentation varying so much - many have come up with ideas and suggestions while scarcely mentioning the continuous ACA exposure supporting these diseases. This is a lifestyle in need of environmental remediation - demonstrated by top researchers - expertise from the most prestigious academic, medical, and government research facilities - upon biopsy, autopsy, and laboratory examination.
MCS 3 Definition and Concensus Criteria
MCS 3a Etiology: Criteria Amendment Research Points (CAR)
MCS 3a AKA Multiple Chemical Sensitivity: 2015 Concensus Criteria
MCS 3aa Etiology: Concensus Author CAR Test (SPC)
MCS 3b Etiology: CAR References A-H including MCS 1, 2, &3
MCS 3b Etiology: CAR References I-Q including MCS 1, 2, &3
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