Multiple Chemical Sensitivity Etiology
Airway Genetics and Ambient Combustion Aerosol
MCS 3b Etiology: References of MCS 3a only
MCS 3b Etiology: CAR References A-H including MCS 1, 2, &3
MCS 3b Etiology: CAR References I-Q including MCS 1, 2, &3
MCS 3b Etiology: CAR References R-Z including MCS 1, 2, &3
MCS 3a Criteria Amendment Research (CAR)
References of MCS 3a only
Adamson A.W. Physical Chemistry of Surfaces. John Wiley, New York, NY 1982
Aeberli I. et al. Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism in healthy young men; a randomized controlled trial. Am J Cl Nutr 94:479-85 2011
Aeberli I. et al. Fructose intake is a predictor of LDL particle size in overweight school children. Am J Cl Nutr 86;4:1174-78 2007
Anand U. et al. TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons. Neurosc Let 438:221-27 2008
Andersson A. et al. Fatty acid composition of skeletal muscle reflects dietary fat composition in humans. Am J Cl Nutr 76;6:1222-9 2002
Andre E. et al. Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 118:2574-82 2008
Apogyan N. et al. Vanilloid receptor activation by 2-and-10-micron particles induces responses leading to apoptosis in human airway epithelial cells. Tox Appl Pharm 192;(1):21-35 2003a
Baeza-Squiban A. et al. Diesel exhaust particles increase NFkB DNA binding activity and c-fos proto-oncogene expression in human bronchial epithelial cells. Tox In Vitro 13 817-22 1999
Baker et al. The nature of the villi in the small intestine of the rat. Lancet 1:860 1963
Baldwin C.M. & Bell I.R. Increased cardiopulmonary disease risk in a community based sample with chemical odor intolerance: implications for women's health and health care utilization. Arch Env H 53(5):347-53 1198
Bang S. et al. Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation . Eur J Neurosc 26:2516-23 2007
Bantle J.P. et al. Effect of dietary fructose on plasma lipids in healthy subjects. Am J Cl Nutr 72;5:1128-34 2000
Bascom R. MCS: A Respiratory Disorder. Tox Ind H 8;4: 221-28 1992 in MCS 6 Neurogenic Inflammation Delayed Effects.
Bascom R. et al. Neurogenic Inflammation: with additional discussion of central and perceptual integration of non-neurogenic inflammation. EHPS 105(2):531-37 1997
Baulig A. et al. Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells.Am J Physiol. Lung Cell mol Physiol 285 L671-679 2003a
Bautista D. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124: 1269-82 2006
Bayram H. et al. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am J Resp Cell Mol Biol 18:441-48 1998
Bell I. et al. Quantitative EEG patterns during nose versus mouth inhalation of filtered room air in young adults with and without self-reported chemical odor intolerances. Int J Psychophys iol 28:23-5 1998
Bell I. Clinically relevant EEG studies and psychophysiological findings: possible neural mechanisms for multiple chemical sensitivity. Toxicol 111:101-17 1996
Bella D.L. et al. Effects of sulfur and nonsulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism. Am J Physiol 277:E144-53 1999
Berg N.D. Genetic sensitivity factors for multiple chemical sensitivity revisited. Int J Hyg Env H 213: 131-39 2010
Bessac B. et al. TRPA1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J 23;4:1102-14 2009
Bessac B. & Jordt S. Breathtaking TRP channels : TRPA1 and TRPV1 in airway chemosensation and reflex control. Phys 23:360-70 2008
Bessac B. et al. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin invest 118:1899-1910 2008a
Bhattacharya M. et al. Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proc Natl acad Sci USA 105:20015-20 2008
Block M.L. et al. The outdoor air pollution and brain health workshop. Neurotox 33:972-84 2012
Block G. et al. Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1. Am J Cl Nutr 94:929-37 2011
Boland S. et al. Mechanisms of GSM-CSF release by diesel exhaust particles in human airway epithelial cells. Am J Phys 278: L25-32 2000
Boland S. et al. Diesel exhaust particles are taken up by human airway epithelial cells in vitro and after cytokine production. Am J Phys 276: L604-13 1999
Bonvallot V. et al. Organic compounds from diesel exhaust particles elicit a pro-inflammatory response in human airway epithelial cells and induce cytochrome P450 1A1 expression. Am J Resp Cell Mol Biol 25: 515-21 2001
Bonvallot V. et al. Activation of transcription factors by diesel exhaust particles in human bronchial epithelial cells in vitro. Inhal Tox 12:359-64 2000
Brone B. et al. Tear gases CN, CR, and CS are potent activators of the human TRPA1 receptor. Tox Appl Pharm 231: 150-6 2008
Burtscher H. et al. Characterization of particles in combustion engine exhaust J Aerosol Sci 29:389-96 1998
Burtscher H. and Schmidt-Ott A. In situ measurement of adsorption and condensation of polyaromatic hydrocarbons on ultrafine c particles by means of photoemission. J Aerosol Sci 17:699-703 1986
Caccamo D. et al. Xenobiotic sensor and metabolism related gene variants in environmental sensitivity related illnesses: a survey on the Italian population. Oxidative Medicine and Cellular Longevity Article ID 831969 9 pages Volume 2013 dx.doi.org/10.1155/2013/831969
Caceres A. et al. A sensory neuronal ion channel essential for airway inflammation and hypereactivity in asthma. PNAS 106;22:9099-9104 2009
Calderon-Garciduenas L. et al. Urban air pollution: influence on olfactory function and pathology in exposed children and young adults. Exp Tox Pathol 62:91-102 2010
Calderon-Garciduenas L. et al. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Tox Pathol 36: 289-310 2008
Calderon-Garciduenas L., Mora-Tiscareno A. et al. Respiratory damage in children exposed to urban pollution. Pediatr Pulmonal 36: 148-61 2003
Calderon-Garciduenas et al. Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants. Am J Resp Crit Care Med 24:132-38 2001
Calderon-Garciduenas L. et al. Respiratory tract pathology and cytokine imbalance in clinically healthy children chronically and sequentially exposed to air pollutants. Med Hyp 55(5): 373-378 2000
Canals S. et al. Nitric oxide triggers the toxicity due to glutathione deletion in midbrain cultures through 12-lipooxygenase. J Biol Chem 278:21542-21549 2003
Chin B.Y. et al. Induction of apoptosis by particulate matter; role of TNF-alpha and MAPK. Am j Physiol 275(5 Pt. 1):1942-9 1998
Chong M.F-F. et al. Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Cl Nutr 85:1511-20 2007
Chun et al. Modulation of CYP3A4 expression by ceramide in human colon carcinoma HT-29 cells. Biochem. Biophys. Res. Commun 298:687-692 2002
Costa S. et al. Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environmental pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ). Arch Toxicol 84(2):109-117 2010
Daniell W.E. et al. Environmental chemical exposures and disturbances of heme synthesis. EHP 105 (1) Feb 1997
Dantoft T.M. et al. An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity. Psychoneuroendocrinology 40: 140-50 2014
Darmaun D. et al. Evidence for accelerated rates of glutathione utilization and glutathione depletion in adolescents with poorly controlled type 1 diabetes. Diabetes 54:190-96 2005
Deluca C. et al. Biological definition of multiple chemical sensiti... from redox state and cytokine profiling and not from polymorphisms of xenobiotic metabolizing enzymes. Tox and Appl Pharm 248: 285-92 2010
Dinis P. Anandamide-evoked activation of vanilloid reeceptor I contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. J Neurosc 24:11253-263 2004
Doty R.L. Olfaction and Multiple Chemical Sensitivity. Tox Ind H 10:4/5: 356-66 1994.
Elberling J. et al. A twin study of perfume-related respiratory symptoms. Int J Hyg Env H 212: 670-78 2009
Elder A. et al. Translocation of inhaled ultrafine manganese oxide particles in the central nervous system. EHP 114:1172-78 2006
Elmquist et al. Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends Neurosc 20:565-70 1997
Escalera J. et al. TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J Biol Chem 283:24136-44 2008
Fda.gov Mercury levels in commercial fish and shellfish 2010
Fisher-Wellman K.H. and Bloomer R.J. Exacerbated postprandial oxida...
stress induced by the acute intake of a lipid meal compared to isoenergetically administered carbohydrate, protein, and mixed meals in healthy young men. Am Coll Nutr 29;4:373-81 2010
Fontana L. et al. 8-Iso-PGF2 alpha induces beta 2-integrin-mediated rapid adhesion of human polymorphonuclear neutrophils: a link between oxidative stress and ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol 21;1:55-60 2001
Friedman M. et al. Effect of unsaturated fats upon lipemia and conjunctival circulation. JAMA 193:882-6 1965
Fung J. et al. Cytochrome P4501A1 in rat peripheral blood lymphocytes: inducibility in vivo and bioactivation of benzo[a]pyrene in the Salmonella typhimurium mutagenicity assay in vitro. Mutat Res 438:1-12 1999
Genter, M.B. Uptake of materials from the nasal cavity into the blood and brain. Ann NY Acad Sc 1170: 623-28 2009
Gerde P. et al. The rapid alveolar absorption of diesel-soot adsorbed benzo[a]pyrene: bioavailability, metabolism, and dosimetry of an inhaled particle-borne carcinogen. Carcinogenesis 22;5:741-49 2001
Gerde P. et al. Benzo{a}pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium. Carcinogenesis 18:1825-32 1997
Gerde P. et al. Particle-associated polycyclic aromatic hydrocarbons - a reappraisal of their possible role in pulmonary carcinogenesis. Toxical Appl Pharmacol 108:1-13 1991
Ginsberg G. et al. Genetic polymorphism in glutathione transferases (GST): population distribution of GSTM1, T1, and P1 conjugating activity. J Toxicol Environ Health B Crit Rev 12:389-39 2009
Goto Y. et al. Particulate matter air pollution stimulates monocyte release from the bone marrow. Am J Resp Crit Care Med 170:891-97 2004
Griffith O.W. & Mulcahy R.T. The enzymes of glutathione biosynthesis y-glutamylcysteine synthetase. Adv Enzymol Relat Areas Mol Biol 73:209-67 1999
Griffith O.W. Biological and pharmalogical regulation of mammalian glutathione synthesis. Free Rad Biol Med 27;9/10:922-35 1999a
Grimble R.F. et al. Cysteine and glycine supplementation modulate the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet. J Nutr 122:2066-73 1992
Hahn M. & Bonkovsky HL. Multiple chemical sensitivity syndrome and porphyria. A note of caution and concern. Arch Int Med 157(3): 281-5 1997
Harmsen A. et al. The role of macrophages in particle translocation from lungs to lymph nodes. Sci 230:1277-80 1985
Hayes J.D. et al. Glutathione Transferases. Ann Rev Pharm Tox 45:51-88 2005
Hayes J.D. & Pulford D.J. The glutathione s-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30:445-600 1995
Hazari M. et al. TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmia in hypertensive rats exposed to diesel exhaust. EHP 119:951-57 2011
Hellerstein M.K. Mitigating factors and metabolic mechanisms in fructose-induced nonalcoholic fatty liver disease: the next challenge. AJCN 96:251-2 2012
Hinman A. et al.TRP channel activation by reversible covalent modification. Proc Nat Acad Sc USA 103:19564-568 2006
Hiraiwa K. & vanEeden S.F. Nature and consequences of the systemic inflammatory response induced by lung inflammation. Provisional Chapter. Intech 2014
Hiraiwa K. & vanEeden S.F. Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollution. Hindawa Med Inflam 2013:ID#619523
Hogg J.C. & vanEeden S.F. Pulmonary and systemic response to atmospheric pollution. Resp 14:336-46 2009
Holst H. et al. Increased capsaicin-induced secondary hyperalgesia in patients with multiple chemical sensitivity. Clin J Pain 2:156-62 2011
Humayan M. et al. Reevaluation of the protein requirement in young men with the indicator amino acid oxidation technique. Am J Cl Nutr 86: 995-1002 2007
Inoue K-i. et al. Effects of nanoparticles on antigen-related airway inflammation in mice. Resp Res 6:106 2005
Jackson A. et al. Synthesis of erythrocyte glutathione consuming safe amount of dietary protein. Am J Cl Nutr 80:101-7 2004
Jakobsen M.U. Intake of carbohydrate comparedwith intake of saturated fats and risk of myocardial infarction: importance of the glycemic index. Am J Cl Nutr 91:1764-8 2010
Jahoor F. et al. Protein deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation. J Nutr 125:1462-72 1995
Jung C.G. Psychological Types. Princeton University Press and in the Portable Jung Viking Press 1921
Kavanagh K. et al. Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates. AJCN 98:349-57 2013
Kennedy G. et al. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Rad Biol & Med 39:584-89 2005.
Khatsenko O. et al. Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. Proc N Acad Sc USA 90:11147-51 1993
Kimata H. Effect of exposure to volatile organic compounds on plasma levels of neuropeptides, nerve growth factor, and histamine in patients with self reported multiple chemical sensitivity. Int J Hyg Env H 207:2 159-63 2004.
Klein-Platat C. et al. Plasma FA concentration is associated with the metabolic syndrome and low grade inflammation in overweight adolescents. Am J CL Nutr 82:1178-84 2005
Kobayashi K. et al. Distinct expression of TRPM8,TRPA1, and TRPV1 in rat primary afferent neurons with adelta/c fibers and colocalization with trk receptors. J Comp Neur 493:596-606 2005
Kumagai Y. et al. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome reductase and involvement of the bioactivation in the DNA damage. Free Rad Biol Med 222:479-87 1997
Latremoliere A. & Woolf C. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10;9:895-926 2009
Lewis J. et al. Trigeminal uptake and clearance of inhaled magnesium chloride in rats and mice. Neurotox 26:113-23 2005
Li J. et al. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. EHO 119:784-93 2011
Liptrott N.J. et al. The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. Br J Pharm 156:497-508 2009
Liu S. et al. A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. 71;6:1455-61 2000
Lucchini R.G. et al. Neurological impacts from inhalation of pollutants and the nose-brain connection. Neurotox (2011) doi:10.1016/j.neuro.2011.12.001 in press
Lukacs N.W. Chemokines and their receptors in chronic pulmonary disease. Curr Drug Targ Inflam Aller 4:313-7 2004
Lundborg M. et al. Ability of rabbit alveolar macrophages to dissolve metals. Exp Lung Res 7:11-22 1984
Lu S.C. Regulation of glutathione synthesis. Mol Asp Med 30;1-2:42-59 2009
Lyons J. et al. Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet. Proc Natl Acad Sc USA 97:5071-6 2000
Macpherson L. et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541-45 2007
Maes M. et al. Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): increased interleukin -1, tumor necrosis factor-alpha, PMN elastase, lysozyme and neopterin. J Aff Dis 136: 933-39 2012
Manfredi S. et al. Glutathione s-transferase T1 and M1-null genotypes and coronary artery disease risk in patients with Type 2 diabetes mellitus. Pharmacogenomics 10:29-34 2009
Materazzi S. et al. Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain 154: 2750-58 2013
Matsui Y. et al. Tracking the pathway of diesel exhaust particles from the nose to the brain by x-ray florescense analysis. Spectrochimica Acta Part B 64: 796-801 2009
McKeown-Eyssen G. et al. Case control study of genotypes in multipl... CYP2D6, NAT1, NAT2, PON1, PON2, and MTHFR. Int J Epidem 33: 970-78 2004
McNamara C. et al. TRPA1 mediates formalin-induced pain. Proc Nat Acad Sc USA 104:31525-30 2007
MCS aa Etiology: Not Always Visible
MCS 11 PM: Trigeminal and Olfactory Pathways
MCS 14 Genetics in Detox Enzymes Not Majority Etiology
MCS 15 Etiology: Airway Genetics
Meggs W.J. Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies. Env H Perspect 105(2): 473-78 1997
Mohankumar S.M.J. et al. Particulate matter, oxidative stress and neurotoxicity. Neurotox 29: 479-88 2008
Molliere M.et al. Metabolism of benzo[a]pyrene in the combined rat liver-lung perfusion system. Tox 45:143-54 1987
Mukae H. et al. The effect of repeated exposure to particulate air pollution (PM-10) on the bone marrow. Am J Resp Crit Care Med 163:201-9 2001
Mutter J. et al. Comments on the article "The Toxicology of Mercury and its Chemical Compounds" by Clarkson and Magos (2006). Crit Rev Tox 37:537-49 2007
Nadin L. et al. Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis alpha. Gastroenterology 109:198-205 1995
Nassenstein C. et al. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 586;6:1595-604 2008
Nassini R. et al. The 'headache tree' via umbellone and TRPA1 activates the trigeminovascular system. Brain doi:10 1093/brain/awr272 2011
Natusch D.F.S. and Tomkins P.A. Theoretical consideration of the adsorption of polynuclear aromatic hydrocarbon vapor onto fly ash in a coal-fired power plant. In Jones P.W. and Freudenthal R.I. (eds) Polynuclear Aromatic Hydrocarbons, Ravan Press, New York, NY 3:145-53 1978
Nogami H. et al. Capsaicin provocation test as a diagnostic method for determining multiple chemical sensitivity. Allergology Int 2: 153-57 2004
Nordin Fredrickson G. et al. Plasma oxidized LDL: a predictor for acute myocardial infarction. Intern Med 253;4:425-29 2003
Nyberg K. et al. Estimation of PH in individual alveolar macrophage phagolysosomes. Exp Lung Res 15:499-510 1989
Orriols R. et al. Brain Dysfunction in Multiple Chemical Sensitivity. J Neurol Sc 287: 72-78 2009
OSHA: Partial list of chemicals in diesel exhaust. 2012
Oslund K. et al. Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. AmJ Respir Cell Mol Biol 39:279-88 2008
Pervin T. et al. Societal Costs of air pollution-related health hazards; A review of methods and results. Cost Ef Res Alloc 6:19 2008
Piacentini S. et al. GSTT1 and GSTM1 gene polymorphisms in European and African populations. Mol Biol Rep 38:1225-30 2011
Pigatto P.O. et al. Allergological and toxicological aspects in a Multiple Chemical Sensitivity cohort. Ox Med Cell Long ID#356235 2013
Robertson M.D. et al. Acute effects of meal fatty acid composition on insulin sensitivity in healthy post menopausal women. Br J Nutr 88:635-40 2002
Roy et al. Susceptibility to pollutant-induced airway inflammation is neurogenically mediated. EPA EIMS Metadata report 59754 2000
Sametz W. et al. Vascular effects of isoprostanes after endothelial damage. Prostaglandins Leukot Essent Fatty Acids 61;6:369-72 1999
Schauer J. et al. Measurement of emissions from air pollution sources. 5. C1-C32 organic compounds from gasoline-powered motor vehicles. Env Sc Tech 36:1169-80 2002
Schauer J. et al. Measurement of emissions from air pollution sources. 3. C1-C29 organic compounds from fireplace combustion of wood. Env Sc Tech 35:1716-28 2001
Schauer J. et al. Measurement of emissions from air pollution sources 2. C1 through C30 organic compounds from medium duty diesel trucks. Env Sc Tech 33:1578-87 1999
Schnakenberg E. et al. A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes. Env H 6:6 2007
Schwartz S.E. et al. Sustained pectin ingestion delays gastric emptying. Gastroenterology 83:812-17 1982
Sekhar R.V. et al. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Cl Nutr 94:847-53 2011
Shi Q. et al. Arterial endothelial dysfunction in baboons fed a high cholesterol high fat diet. Am J Cl Nutr 82:751-9 2005
Siri-Tarino P.W. et al. Saturated fat, carbohydrate, and cardiovascular disease. Am J Cl Nutr 91: 502-9 2010
Society of Automotive Engineers. Schematic of diesel particles and vapor phase compounds. SAE Paper no. 940233 1994
Stadler J. et al. Inhibition of cytochromes P4501A1 by nitric oxide. Proc Natl Acad Sci USA 91:3559-63 1994
Sterner-Kock A. et al. Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils. J Leukoc Biol 65:1834-40 1999
Stone V. et al. The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Tox in vitro 12:649-59 1998
Symanowicz P. et al. Lack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57B1/6J mouse. Neurosc Lett 362:150-3 2004
Tanabe T. et al. Intracellular signaling pathway of substance P-induced superoxide production in human neutrophils. Eur J Pharmacol 299:187-95 1996
Tapner M. et al. Interferon gamma down-regulates cytochrome P450 3A genes in primary cultures of well-differentiated rat hepatocytes. Hepatology 24:367-73 1996
Taylor-Clark T. & Undem B. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol 588;3:423-33 2010
Terlecky S. et al. Peroxisomes and Aging. Biochim Biophys Acta 1763;12:1749-54 2006
Thomas R. et al. ETS1, NFkB and AP-1 synergistically transactivate the human GM-CSF promoter. Oncogene 14:Z845-55 1997
Thompson C.L et al. Relationships among benzo[a]pyrene metabolism benzo[a]pyrene-dial-epoxide DNA adduct formation and sister chromatid exchanges in human lymphocytes from smokers and nonsmokers. Cancer Res 49:6501-11 1989
Tinel M. et al. Interleukin 2 overexpresses c-myc and down regulates cytochrome P-450 in rat hepatocytes. J Pharm Exp Ther 289:649-55 1999
Tran et al. Multiple chemical sensitivity: on the scent of central sensitization. Int J Hyg Ind H 216(2):202-10 2013
US DOT FHA Addendum to the 1997 Federal Highway Cost Allocation Study. Final report. May 2000
Veronesi B. & Oortgiesen M. The TRPV1 receptor: target of toxicants and therapeutics. Tox Sc 89(1):1-3 2006
Veronesi B. and Oortgiesen M. Neurogenic inflammation and particulate matter (PM) air pollutants. Neurotox 22: 795-810 2001
Veronesi B. et al. Vanilloid capsaicin receptors influence inflammatory sensitivity in response to particulate matter. Tox Appl Pharm 15;169(1): 66-76 2000
World Almanac 2011: International Data Base, International Programs Center, US Census Bureau, US Dept of Commerce and the World Factbook, Central Intelligence Agency
Wu G. et al. Glutathione metabolism and its implications for health. J Nutr 134:489-92 2004
Yang Y. et al. Endothelial glutathione-s-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-kappa B translocation. Tox Appl Pharm 230:187-96 2008
Yeh H.C. et al. Comparisons of calculated respiratory tract deposition of particles based on the proposed NCRP model and the new ICRP66 MODEL. Aer Sci Tech 25:134-40 1996
Ziedinski H. et al. Modeling the interactions of particulates with epithelial lining fluid antioxidants. Am J Phys 277:L719-26 1999
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