MCS 2a Etiology: Notes on References

[michael edward badolato jr]

MCS 1a 2019 MCS Consensus Criteria

MCS 2 The Etiology of MCS

MCS 2a Etiology: TRPA1 Precision

MCS 2a Etiology: Notes on References 

MCS 2ab Etiology: Nasal Cytokines in Context

MCS 2 The Etiology of MCS 

MCS 3 Definition and Consensus Criteria

MCS 3a Etiology: Criteria Amendment Research (CAR)

MCS 3a AKA Multiple Chemical Sensitivity: 2019 Consensus Criteria

MCS 3aa Etiology: Consensus Author CAR Test (SPC)

MCS 3b Etiology: CAR References A-H including MCS 1, 2, &3

MCS 3b Etiology: CAR References I-Q including MCS 1, 2, &3

MCS 3b Etiology: CAR References R-Z including MCS 1, 2, &3

MCS 3b Etiology: References of MCS 3a only

MCS 3g CAR Nutritional Considerations

MCS ad Etiology: Naturally Sensitive

MCS ae Etiology: Airway Reactivity

MCS af Etiology: Central Sensitization

References are of research authorities - conclusions reached in extensive reviews. All statements are documented with the most credible evidence.

Numerical designations (1-15) are sections of MCS 2: The Etiology of MCS

1)2)3) Elberling 2009 - study results consistent with Veronesi 2001 review and Roy 2000 EPA metadata report

Veronesi 2001 - review of studies basis for Roy 2000 EPA metadata report   

Jung 1921 - one of the most monumental works in the field of Psychology - consistent with EPA metadata report

4) Deering-Rice 2011, Li 2011, Taylor-Clark 2010,  Baulig 2009, 2003a,  Calderon-Garciduenas 2008, 2000, Gerde 2001, and Veronesi 2001 - studies and reviews of advancing precision, high credibility, review discussions building on foundation - consistent with Roy 2000 EPA metadata report

OSHA 2012, Block 2009, Schauer 2002, 2001, 1999 - Block 2009 is review concerning effects of aerosol, the remainder measure and define components of aerosol

Lucchini 2012, Mohankumar 2008,  Inoue 2005,  Cadle 1999, Kleeman 1999, Kittelson 1998, - define and review effects of nanoparticles

Calderon-Garciduenas 2010 - credible research authority - autopsies confirm PM in CNS olfactory bulb

Matsui 2009 - confirm PM via olfactory neurons to the CNS

Elder 2006 and Lewis 2005 - confirm trigeminal pathway for PM to the CNS

5) Deluca 2010 - important study - MCS plasma measurements - with expanded review discussion

Kimata 2004 - important study - MCS plasma measurements - expected and consistent with Veronesi 2001 review, Roy 2000 metadata report, findings of Bascom 1992 MCS 6, Meggs 1997, Millquist 2005, Nogami 2004 - and the reviews of Latremoliere 2009, Bessac 2008, Nassenstein 2008, and Nilius 2007

6) Deering-Rice 2011 and Taylor-Clark 2010, - studies of advanced precision with review discussion, very important, expected and consistent with Bessac 2008 review.

Bessac 2008 - advanced review on TRP receptors - consistent and building on Veronesi 2001 review and EPA metadata report

Nassenstein 2008 - study with discussion building on Bessac 2008

Nilius 2007 - extensive review on TRP with 543 references - again consistent

all of the above consistent with Roy 2000 EPA metadata report and review discussions of Costa 2010, Oslund 2008, Mohankumar 2008, Calderon-Garciduenas 2008,  Veronesi 2001, Meggs 1997, and Bascom 1992 MCS 6

7) Meggs 1997 - MCS biopsy results - tight junction defects, focal desquamation, multiplied nerves, thickened basement membrane, lymphocytic infiltrates - and review discussion consistent with Veronesi 2001 review, Roy 2000 metadata report, and numerous studies and reviews including those mentioned above

Meggs 1996 - MCS biopsy results

Meggs 1993 - MCS rhinoscopy results

8) Millquist 2005 - measure MCS nerve growth factor increase on capsaicin provocation - expected and consistent

Nogami 2004 - MCS airway reactivity on capsaicin provocation - expected and consistent

Lee and Pisarri 2001 - review of airway reactivity

Bonham 2001 - measure reactivity and review discussion

Castranova 2002 - review including study of nerve multiplication

Kimata 2004 - MCS plasma measurements including nerve growth factor - expected and consistent

Bascom 1992 MCS 6 - review of findings at the Environmental and Airway Disease research Facility at the Univ of MD - consistent with Veronesi 2001 review, Roy 2000 EPA metadata report and numerous studies and reviews including those mentioned above

Doty 1994 - measure MCS airway resistance and respiratory rate - expected and consistent

Tran 2013 - measure MCS hyperalgesia - consistent with review of Latremoliere 2009

Latremoliere 2009 - very important review of central sensitization - 408 references

Kunkler 2011 - very important review discussion of TRPA1 and meningeal vasodilitation

Nassini 2011 - very important confirmation of TRPA1 pathway - expected and consistent   

Jordt 2011  - review including statement of trigeminal-olfactory-opthalmic connection

Finger 1993 - determination of trigeminal-olfactory-opthalmic connection consistent with Jordt 2011

9) Orriols 2009 - important study of MCS CNS function with review discussion

Bell 1999 - review of MCS CNS studies

Bell 1998 - MCS measured alterations - consistent with review

10) Deluca 2010 - MCS plasma measurements and important review discussion of oxidative stress chain reaction 

Calderon-Garciduenas 2008 - advanced authority - including autopsy work - airway accompanying CNS disease - expected and consistent 

Yang 2008 - review discussion concerning 4-HNE - consistent with Deluca 2010

Terlecky 2006 - review includes catalase deficiency - consistent with Deluca 2010

Kennedy 2005 - review discussion concerning oxidative stress - consistent with Deluca 2010

Daniell 1997 - review of MCS porphyrin abnormalities (disturbances in heme synthesis)

Hahn 1997 - important cautions for MCS people concerning porphyrin abnormalities

Emch 2000 - study and review showing that cytokine TNF alpha causes gastrointestinal stasis via vagal circuitry - perceived as queasiness

11) Berg 2010 and Deluca 2010 - important large studies of diagnosed MCS groups including measurements of genetics in detox compared to controls

12) Schnakenberg 2007, Mckeown-Eyssen 2004, and Haley 1999 - studies often misapplied to MCS

13) Block 2011 - study and review discussion of GSTM1 and GSTT1 deletions including percent occurrence in the population

Piacentini 2011,  Ginsberg 2009, Hayes 1995 - consistent with Block 2011

14) Lu 2009, Wu 2004, Griffith 1999 - reviews of glutathione synthesis and metabolism

Oslund 2008, Sterner-Kock 1999, Tanabe 1996 - substance P and NO production

Canals 2003 - NO production and glutathione depletion

Darmaun 2005 - example and discussion of excessive glutathione utilization

15) a summation with references repeated

  

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