Multiple Chemical Sensitivity Etiology
Airway Genetics and Ambient Combustion Aerosol
MCS A-1 Etiology: References
MCS A-1 Etiology: Dantoft 2014
MCS 3 Definition and Concensus Criteria
MCS 3a Etiology: Criteria Amendment Research Points (CAR)
MCS 3aa Etiology: Concensus Author CAR Test (SPC)
MCS 3b Etiology: CAR References A-K
MCS 3b Etiology: CAR References L-Z
MCS 3c Etiology: CAR Documentation
MCS 3d Etiology: CAR Case Example
MCS 3e Etiology: CAR Impossibly Good City Design
MCS 3f Etiology: Criteria Amendment Q and A
MCS 3g CAR Nutritional Considerations
References
Agopyan N et al. Negatively charged 2 and 10 micron particles activate vanilloid receptors, increase cAMP, and induce cytokine release. Tox and Appl Pharm 186(2): 63-76 2003
Apogyan N. et al. Vanilloid receptor activation by 2-and-10-micron particles induces responses leading to apoptosis in human airway epithelial cells. Tox Appl Pharm 192;(1):21-35 2003a
Anand U. et al. TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons. Neurosc Let 438:221-27 2008
Bai N. et al. The pharmacology of particulate matter air pollution-induced cardiovascular dysfunction. Pharmacology and Therapeutics 113:16-29 2007
Bandell M. et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41:849-57 2004
Bhattacharya M. et al. Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proc Natl acad Sci USA 105:20015-20 2008
Baulig A.et al.Role of Paris PM 2.5 components in the pro-inflammatory response induced in airway epithelial cells. Tox 261: 126-35 2009
Baulig A. et al. Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells.Am J Physiol. Lung Cell mol Physiol 285 L671-679 2003a
Bautista D. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124: 1269-82 2006
Bedard A. and Parent A. Evidence of newly generated neurons in the human olfactory bulb. Dev Brain Res 151: 159-68 2004
Bell I. et al. Quantitative EEG patterns during nose versus mouth inhalation of filtered room air in young adults with and without self-reported chemical odor intolerances. Int J Psychophys iol 28:23-5 1998
Bell I. Clinically relevant EEG studies and psychophysiological findings: possible neural mechanisms for multiple chemical sensitivity. Toxicol 111:101-17 1996
BERG N.D. GENETIC SUSCEPTIBILITY FACTORS FOR MULTIPLE CHEMICAL SENSITIVITY REVISITED. Int J Hyg Env H 213: 131-39 2010
Bessac B. & Jordt S. Breathtaking TRP channels : TRPA1 and TRPV1 in airway chemosensation and reflex control. Phys 23:360-70 2008
Bessac B. et al. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin invest 118:1899-1910 2008a
Blau J. & Solomon F. Smell and other sensory disturbances in migraine. J Neurol 232:275-76 1985
Block M.L. et al. The outdoor air pollution and brain health workshop. Neurotox 33: 972-84 2012
Block M.L.and Calderon-Garciduenas L. Air pollution: mechanisms of neuroinflammation & CNS disease. Trends Neuro 32(9): 506-16 2009
Block M.L. et al. Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons; the role of microglia, phagocytosis, and NADPH oxidase. FASEB 10.1096/fj.041945fje 2004
Bond J.A. et al. Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs. Drug Metab Dispos 16:116-24 1988
Bonvallot V. et al. Organic compounds from diesel exhaust particles elicit a pro-inflammatory response in human airway epithelial cells and induce cytochrome P450 1A1 expression. Am J Resp Cell Mol Biol 25: 515-21 2001
Bonvallot V. et al. Activation of transcription factors by diesel exhaust particles in human bronchial epithelial cells in vitro. Inhal Tox 12:359-64 2000
Boyman O. & Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat Rev Immunol 12:180-90 2012
Burtscher H. et al. Characterization of particles in combustion engine exhaust J Aerosol Sci 29:389-96 1998
Burtscher H. and Schmidt-Ott A. In situ measurement of adsorption and condensation of polyaromatic hydrocarbons on ultrafine c particles by means of photoemission. J Aerosol Sci 17:699-703 1986
Caccamo D. et al. Xenobiotic sensor and metabolism related gene variants in environmental sensitivity related illnesses: a survey on the Italian population. Oxidative Medicine and Cellular Longevity Article ID 831969 9 pages Volume 2013 dx.doi.org/10.1155/2013/831969
Cadle S.H et al. Composition of light duty motor vehicle particulat... in the Denver, Colorado area. Env Sc Tech 33;14: 2328-39 1999
Calderon-Garciduenas L. et al. Exposure to severe air pollution influences cognitive outcomes, brain volume, and systemic inflammation in clinically healthy children. Brain and Cognition 77:345-55 2011
Calderon-Garciduenas L. et al. Urban air pollution: influence on olfactory function and pathology in exposed children and young adults. Exp Tox Pathol 62:91-102 2010
Calderon-Garciduenas L. et al. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Tox Pathol 36: 289-310 2008
Calderon-Garciduenas L. et al. Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution. Tox Pathol 32: 650-58 2004
Calderon-Garciduenas L., Maronpot R.R. et al. DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration. Tox Pathol 31: 524-38 2003
Calderon-Garciduenas L., Mora-Tiscareno A. et al. Respiratory damage in children exposed to urban pollution. Pediatr Pulmonal 36: 148-61 2003
Calderon-Garciduenas L. et al. Air pollution and brain damage. Tox Pathol 30: 373-89 2002
Calderon-Garciduenas L. et al. Respiratory tract pathology and cytokine imbalance in clinically healthy children chronically and sequentially exposed to air pollutants. Med Hyp 55(5): 373-378 2000
Chin B.Y. et al. Induction of apoptosis by particulate matter; role of TNF-alpha and MAPK. Am j Physiol 275(5 Pt. 1):1942-9 1998
Dai Y. et al. Sensitization of TRPA1 by PAR 2 contributes to the sensation of inflammatory pain. J Clin Invest 117:1979-87 2007
Danahay H. et al. Interleukin 13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 282: L226-36 2002
Daniell W.E. et al. Environmental chemical exposures and disturbances of heme synthesis. EHP 105 (1) Feb 1997
Dantoft T.M. et al. An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity. Psychoneuroendocrinology 40: 140-50 2014
Deluca C. et al. Biological definition of multiple chemical sensiti... from redox state and cytokine profiling and not from polymorphisms of xenobiotic metabolizing enzymes. Tox and Appl Pharm 248: 285-92 2010
Elberling J. et al. A twin study of perfume-related respiratory symptoms. Int J Hyg Env H 212: 670-78 2009
Elder A. et al. Translocation of inhaled ultrafine manganese oxide particles in the central nervous system. EHP 114:1172-78 2006
Friedman D. & De ver Dye T. Migraine and the environment. Headache 49: 941-52 2009
Gavett S.H. et al. Capsaicin receptor antagonist and c-fiber depletion reduce pulmonary responses to particulate matter in BALB/c mice. The Toxicologists 18:405 1998
Genter, M.B. Uptake of materials from the nasal cavity into the blood and brain. Ann NY Acad Sc 1170: 623-28 2009
Gerde P. et al. The rapid alveolar absorption of diesel-soot adsorbed benzo[a]pyrene: bioavailability, metabolism, and dosimetry of an inhaled particle-borne carcinogen. Carcinogenesis 22;5:741-49 2001
Gerde P. et al. Benzo{a}pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium. Carcinogenesis 18:1825-32 1997
Gillespie P. et al. Particulate matter neurotoxicity in culture is size dependant. Neurotox 36: 112-17 2013
Hahn M. & Bonkovsky HL. Multiple chemical sensitivity syndrome and porphyria. A note of caution and concern. Arch Int Med 157(3): 281-5 1997
Hayes A. et al. Effects of neonatal administration of capsaicin on nociceptive thresholds in the mouse and rat. J Pharm Pharmacol 33;3:183-85 1981
Hazari M. et al. TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmia in hypertensive rats exposed to diesel exhaust. EHP 119:951-57 2011
Hinman A. et al.TRP channel activation by reversible covalent modification. Proc Nat Acad Sc USA 103:19564-568 2006
Holroyd K. et al. Genetic modeling of susceptibility to nitrogen dioxide-induced lung injury in mice. Am J Physiol 273;1-3:L595-602 1997
Holst H. et al. Increased capsaicin-induced secondary hyperalgesia in patients with multiple chemical sensitivity. Clin J Pain 2:156-62 2011
Ichinose T. et al. Murine strain differences in allergic airway inflammation and immunoglobulin production by a combination of antigen and diesel exhaust particles. Tox 122;3:183-92 1997
Inoue K-i. et al. Effects of nanoparticles on antigen-related airway inflammation in mice. Resp Res 6:106 2005
Lewis J. et al. Trigeminal uptake and clearance of inhaled magnesium chloride in rats and mice. Neurotox 26:113-23 2005
Jordt S. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260-65 2004
Jung C.G. Psychological Types. Princeton University Press and in the Portable Jung Viking Press 1921
Kelman I. The triggers or precipitants of the acute migraine attack. Cephalagia 27:394-402 2007
Kimata H. Effect of exposure to volatile organic compounds on plasma levels of neuropeptides, nerve growth factor, and histamine in patients with self reported multiple chemical sensitivity. Int J Hyg Env H 207:2 159-63 2004.
Kittelson D.B. Engines and nanoparticles: a review. J Aerosol Sci 29: 575-88 1998
Kleeberger S. Genetic susceptibility to ozone exposure. Tox Lett 82-83:295-300 1995
Kleeman M.J. et al. Size and composition distribution of fine particle matter emitted from woodburning, meat charbroiling, and cigarettes. Env Sc Tech 33;20: 3516-23 1999
Kobayashi K. et al. Distinct expression of TRPM8,TRPA1, and TRPV1 in rat primary afferent neurons with adelta/c fibers and colocalization with trk receptors. J Comp Neur 493:596-606 2005
Latremoliere A. & Woolf C. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10;9:895-926 2009
Lewis J. et al. Trigeminal uptake and clearance of inhaled magnesium chloride in rats and mice. Neurotox 26:113-23 2005
Li J. et al. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. EHO 119: 784-93 2011
Lucchini R.G. et al. Neurological impacts from inhalation of pollutants and the nose-brain connection. Neurotox (2011) doi:10.1016/j.neuro.2011.12.001 in press
MCS 9 Etiology:Airway Origins PM and a Defective Scrubber.
MCS 10 Etiology: Credible Proof: The Study of all Studies.
MCS 11 Etiology: PM Trigeminal and Olfactory Pathways.
MCS 15 Etiology: Airway Genetics
Macpherson L. et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541-45 2007
Materazzi S. et al. Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain 154: 2750-58 2013
Matsui Y. et al. Tracking the pathway of diesel exhaust particles from the nose to the brain by x-ray florescense analysis. Spectrochimica Acta Part B 64: 796-801 2009
McKeown-Eyssen G. et al. Case control study of genotypes in multipl... CYP2D6, NAT1, NAT2, PON1, PON2, and MTHFR. Int J Epidem 33: 970-78 2004
Meggs W.J. Arch Env H 54(5) 309-11 1999
Meggs W.J. Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies. Env H Perspect 105(2): 473-78 1997
Meggs W.J. et al. Nasal pathology and ultrastructure in patients with chronic airway inflammation (RADS and RUDS) following an irritant exposure. J Tox Clin Tox 34;4: 383 1996
Meggs W.J. Neurogenic Inflammation and sensitivity to environmental chemicals. EHP 101;3:234-38 1993
Meggs W.J. and Cleveland Jr. C.H. Rhinolaryngoscopic examination of patients with multiple chemical sensitivity syndrome. Arch Env H 48: 1-14 1993a
Millqvist E. et al. Changes in level of nerve growth factor in nasal secretions after capsaicin inhalation in patients with airway symptoms from scents and chemicals. EHP 113;7: 844-52 2005
Minty A. et al. Interleukin 13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362: 248-50 1993
Miyabara Y. et al. Murine strain differences in airway inflammation caused by diesel exhaust particles. Eur Resp J 11: 291-98 1998
Miyabara Y. et al. Diesel exhaust enhances allergic airway inflamma... and hyperesponsiveness in mice. Am J Resp Crit Care Med 157: 1138-44 1998a
Mohankumar S.M.J. et al. Particulate matter, oxidative stress and neurotoxicity. Neurotox 29: 479-88 2008
Nassini R. et al. The 'headache tree' via umbellone and TRPA1 activates the trigeminovascular system. Brain doi:10 1093/brain/awr272 2011
Nielsen G.D. Mechanisms of activation of the sensory irritant receptor by airborne chemicals. Crit Rev Tox 21:3:183-208 1991
Nogami H. et al. Capsaicin provocation test as a diagnostic method for determining multiple chemical sensitivity. Allergology Int 2: 153-57 2004
Oortgiesen et al. Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. Am J Physiol Lung Cell Mol Physiol 278: L683-95 2000
Orriols R. et al. Brain Dysfunction in Multiple Chemical Sensitivity. J Neurol Sc 287: 72-78 2009
OSHA: Partial list of chemicals in diesel exhaust.
Oslund K. et al. Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. AmJ Respir Cell Mol Biol 39:279-88 2008
Pakkanen T.A. et al. Size distributions of mass and chemical compon... in street-level and rooftop PM1 particles in Helsinki. Atmosph Env 37: 1673-90 2003
Parham P. et al. The immune system. 3rd ed. Garland Science, Taylor & France group, LLC 2009
Prior M. et al. Capsaicin pretreatment modifies hydrogen sulphide-induced pulmonary injury in rats. Tox Pathol 18;2:279-88 1990
Punnonen J. et al. Interleukin 13 induces interleukin 4-interdependent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 90:3730-34 1993
Roy et al. Susceptibility to pollutant-induced airway inflammation is neurogenically mediated. EPA EIMS Metadata report 59754 2000
Ruckerl R et al. Air pollution and inflammation (interleukin 6, C-reactive protein, fibrinogen) in myocardial infarction survivors. EHP 115;7:1072-80 2007
Salmon P. et al. Cognitive abilities mediated by frontal-subcortical circuits. Chapter 5 in: Lichter D.G. & Cummings J.L. editors. Frontal-subcortical circuits in psychiatric and neurological disorders. New York: The Guilford Press: 114-50 2001
Satoh H. et al. Inhibitory effects of capsazepine and SR 48968 on citric acid-induced bronchoconstriction in guinea-pigs. Eur J Pharm 236;3:367-72 1993
Schauer J. et al. Measurement of emissions from air pollution sources. 5. C1-C32 organic compounds from gasoline-powered motor vehicles. Env Sc Tech 36:1169-80 2002
Schauer J. et al. Measurement of emissions from air pollution sources. 3. C1-C29 organic compounds from fireplace combustion of wood. Env Sc Tech 35:1716-28 2001
Schauer J. et al. Measurement of emissions from air pollution sources 2. C1 through C30 organic compounds from medium duty diesel trucks. Env Sc Tech 33:1578-87 1999
Scheerens H. et al. The involvement of sensory neuropeptides in toluene diisocyanate-induced tracheal hyperreactivity in the mouse airways. Br J Pharm 119;8:1665-71 1996
Schnakenberg E. et al. A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes. Env H 6:6 2007
Society of Automotive Engineers. Schematic of diesel particles and vapor phase compounds. SAE Paper no. 940233 1994
Steerenberg P.A. et al. Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro. Exp Lung Res 24: 85-100 1998
Sterner-Kock A. et al. Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils. J Leukoc Biol 65:1834-40 1999
Tanabe T. et al. Intracellular signalling pathway of substance P-induced superoxide production in human neutrophils. Eur J Pharmacol 299:187-95 1996
Taylor-Clark T. & Undem B. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol 588;3:423-33 2010
Tran et al. Multiple chemical sensitivity: on the scent of central sensitization. Int J Hyg Ind H 216(2):202-10 2013
US DOT FHA Addendum to the 1997 Federal Highway Cost Allocation Study. Final report. May 2000
Veronesi B. et al. Effects of subchronic exposure to concentrated ambient particles VII Degeneration of dopaminergic neurons in APO E-1 mice. Inhal Tox 17; 4-5: 235-41 2005
Veronesi B. et al. Electrostatic charge activates inflammatory vanilloid (VR1) receptors. Neurotox 24: 463-73 2003
Veronesi B. et al. The surface charge of visible particulate matter predicts biological activation in human bronchial epithelial cells. Tox and Appl Pharm 178: 144-54 2002a
Veronesi B. et al. Particulate matter inflammation and receptor sensitivity are target cell specific. Inhal Tox 14(2): 159-83 2002b
Veronesi B. and Oortgiesen M. Neurogenic inflammation and particulate matter (PM) air pollutants. Neurotox 22: 795-810 2001
Veronesi B. et al. Vanilloid capsaicin receptors influence inflammatory sensitivity in response to particulate matter. Tox Appl Pharm 15;169(1): 66-76 2000
Veronesi B. et al. Particulate matter initiates inflammatory cytoki... by activation of capsaicin and acid receptors in a human bronchial epithelial cell line. Tox and Appl Pharm 154: 106-15 1999a
Veronesi B.et al. Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. Neuropep 33;6: 447-56 1999b
Voigt J.M. et al. Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa. J Hystochem Cytochem 41:877-85 1993
Yadav A. et al. MCP-1: Chemoattractant with a role beyond immunity. A review. Clinica Chimica Acta 411:1570-79 2010
Yeadon M. et al. Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharm 5;1:39-50 1992
Zhang L. Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice. Exp Lung Res 21;4:503-18 1995
Zhu G. et al. Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. Hum Mol Gen 18(11):2053-62 2009
Views: 205
About
© 2024 Created by michael edward badolato jr.
Powered by
