Multiple Chemical Sensitivity Etiology

Airway Genetics and Ambient Combustion Aerosol

Impossibly Good

A slower paced, reduced consumption, non combustion lifestyle is needed or human beings will go extinct due to loss of environment and resources.

Mgt 101 Consume Less or Extinction

Mgt 101a Impossibly Good City Design


9 Point Summary:

1) Man began cooking and heating with fire. Inhaling smoke predisposed for infections limiting life expectancy (Boman 2006).

2) Man developed antibiotics preventing fatality from infections greatly increasing life expectancy  despite the inhalation of smoke and liquid fuel combustion byproducts (Yoshikawa 2000).

3) Smoke and liquid fuel combustion byproducts - combined with individual genetic vulnerability - plague the second half of life with degenerative disease due to penetration of particle agglomerates with adsorbed hydrocarbons and singlet non-agglomerated nanoparticles

Deering-Rice 2011, Hazari 2011, Li 2011, Taylor-Clark 2010Baulig 2009, 2003aCalderon-Garciduenas 2008, 2000Veronesi 2003, 2002a, 2002b, 2001, 2000, 1999a, 1999b, Agopyan 2003, Bonvallot 2001, 2000, Gerde 2001, 1997Oortgiesen 2000, Roy 2000, Miyabara 1998,1998a, Steerenberg 1998, Meggs 1997

OSHA 2012, Block 2009, Pakkanen 2003, Schauer 2002, 2001, 1999, US DOT FHA 2000, Society of Automotive Engineers SAE 940233 1994

Lucchini 2012, Mohankumar 2008,  Inoue 2005, Kittelson 1998, Cadle 1999, Kleeman 1999  

Fine particles expected to reach the CNS via trigeminal and olfactory nerve pathways

MCS 11, Calderon-Garciduenas 2010Genter 2009, Matsui 2009, Elder 2006Lewis 2005

4) Diseases due to smoke - wood and tobacco - and liquid fuel combustion byproducts - diesel, gasoline, propane, white gas - include Multiple Chemical Sensitivity (Deering-Rice 2011, Kunkler 2011,Taylor-Clark 2010, Bessac 2008, Nassenstein 2008, Nilius 2007), Alzheimers (Calderon-Garciduenas 2008), Parkinsons (Block 2009, 2004, Calderon-Garciduenas 2008, Veronesi 2005), cancer (Krivoshto 2008), chronic obstructive pulmonary disease (Li 2011), and exascerbation of heart disease (Hazari 2011).

5) Exposure of mother and developing fetus to the continuous combustion byproduct aerosol has increased autism in newborn children.

VOLK 2012:

"...Exposure to traffic-related air pollution, nitrogen dioxide, PM 2.5 and PM 10 during pregnancy and the first year of life was associated with autism..."

BECERRA 2012:

"...Measured and estimated exposures from ambient pollutant monitors and LUR model suggest associations between autism and prenatal air pollution exposure, mostly related to traffic sources...

...12-15% relative increase in odds of autism for 03 (ozone)...per 11.54 ppb increase and PM 2.5 per 4.68 ug/m3 increase..."

VOLK 2011:

"...Living near a freeway was associated with autism...

...Autism is a developmental disorder characterized by significant deficits in social interaction and communication, accompanied by repetitive behaviors (American Psychiatric Association 2000)...

...autism has been associated...with diesel PM exposure in early childhood (Windham 2006)...

...Recent work examining the effects of benzo[a]pyrene, a common PAH, indicates that prenatal oral exposure in mice results in decreased neuronal plasticity and behavioral deficits (Brown 2007)..."

6) Abundant energy from combustion sources has resulted in unrestrained proliferation - population growth and consumption - and near complete loss of morality. Knowledge on this subject has been applied to developing drugs and futile emission control strategies - rather than changing the lifestyle.

7) Though often hard working with great achievement - there is conformity to an immoral lifestyle - drive instead of walk, thermostats set high, junk food instead of wholesome, violent entertainment, mostly oblivious of the environment - and a willingness to take drugs as a solution.

8) That people would recognize morally deficient social values and change behavior seems impossible. Required is a moral and intellectual exertion - a self scrutiny of one's own attitude, character, behavior, and motives - and a rejection of wasteful activities and products.

9) Good God, spirits of the universe, or whatever you believe - we have to be Impossibly Good.

 

Mgt 101 Consume Less or Extinction

Mgt 101a Impossibly Good City Design  

Love 201 20 Commandments: Who's Overdoing It?

Love 202 20 Alternatives

Multiple Chemical Sensitivity Etiology

Airway Genetics and Ambient Combustion Aerosol

Correct etiology applied to the majority of cases.

Sheds light on pollution caused disease in general - including MCS, Alzheimers, Parkinsons, cancer, COPD, and exascerbation of heart disease.

Recognizes there is no safe level of smoke and vehicle exhaust.

To quickly locate use search words MCS Etiology.

 

References

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American Psychiatric Association. Diagnosis and Statistical Manual of Mental Disorders 4th ed. Text Revision. Washington, DC 2000

increase cAMP, and induce cytokine release. Tox and Appl Pharm 186(2): 63-76 2003

Baulig A.et al.Role of Paris PM 2.5 components in the pro-inflammatory response induced in airway epithelial cells. Tox 261: 126-35 2009

Baulig A. et al. Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells.Am J Physiol. Lung Cell mol Physiol 285 L671-679 2003a 

BECERRA T.A. ET AL. AMBIENT AIR POLLUTION AND AUTISM IN LOS ANGELES COUNTY CALIFORNIA. EHP 2012 EPUB AHEAD OF PRINT

Bessac B. & Jordt S. Breathtaking TRP channels : TRPA1 and TRPV1 in airway chemosensation and reflex control. Phys 23:360-70 2008

Block M.L.and Calderon-Garciduenas L. Air pollution: mechanisms of neuroinflammation & CNS disease. Trends Neuro 32(9): 506-16 2009

Block M.L. et al. Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons; the role of microglia, phagocytosis, and NADPH oxidase. FASEB 10.1096/fj.041945fje 2004

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Bonvallot V. et al. Activation of transcription factors by diesel exhaust particles in human bronchial epithelial cells in vitro. Inhal Tox 12:359-64 2000

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Mgt 104 Respirators: Particles and Adsorbed Hydro.... mcsmultiplechemicalsensitivity.ning.com 2012 

MCS 9 Airway Origins: PM and a Defective Scrubber. 

MCS 10 Credible Proof: The Study of all Studies. 

MCS 11 PM: Trigeminal and Olfactory Pathways.

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Nassenstein C. et al. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Phys 586:1595-604 2008

Nassini R. et al. The 'headache tree' via umbellone and TRPA1 activates the trigeminovascular system. Brain doi:10 1093/brain/awr272  2011

Nilius B. et al. Transient receptor potential cation channels in disease. Physiol Rev 87:166-217 2007

Oortgiesen et al. Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. Am J Physiol Lung Cell Mol Physiol 278: L683-95 2000

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