Airway Genetics and Ambient Combustion Aerosol

SPC 13 Exposed Sensory Nerves - TRPA1

SPC 13 Exposed Sensory Nerves - TRPA1

Links: 35 CAR Test SPC Questions
CAR Warm Up
SPC 1 Introduction: South Pole CAR (SPC) - A Character Test
SPC 2 South Pole CAR: ACA PM, Band Cell, and Monocyte Drop
SPC 3 ACA PM and ME/CFS: Do We Hear An Echo?
SPC 4 ACA UFPM: In the RBC - Through the BBB
SPC 5 ACA UFPM: IL-1 beta, RBC, BBB, - MCS and ME/CFS
SPC 6 ACA UFPM: Nerve Penetration
SPC 7 ACA UFPM: Olfactory, BBB, AD, PD, MCS, and ME/CFS
SPC 8 ACA PM: Gastro-Inflammation, Immunity, Vagal Circuitry
SPC 9 Veronesi: Sensory Nerve Insight
SPC 10 Kimata: Histamine Warning - Return to Masking
SPC 11 Central Sensitization: Intense, Repeated, and Sustained Inputs

On CAR
SPC 12 Disease Conditions Begin: Airway Epithelial Injury
SPC 13 Exposed Sensory Nerves - TRPA1
SPC 14 Exposed TRPA1: Central Sensitization
SPC 15 ACA: Loud and Clear
SPC 16 Airway Cytokine Release: Principle Mediator of Systemic Inflammation
SPC 17 Calderon-Garciduenas: Airway to Systemic: Putting It Together
SPC 18 Airway Gaps - Exposed Nerves - UFPM to the CNS
SPC 19 ACA PM: Months and Years Residence Time
SPC 20 Airway Gaps: Reduced Detox Enzyme Intervention
SPC 21 Solvents and Pesticides Primary: Shoe Fits Glove?
SPC 22 Veronesi and Roy: Genetic Difference in Airway Sensitivity

SPC 23 Jung Was Right Sort Of
SPC 24 Veronesi and Jung: A Perfect Match
SPC 25 Tailpipe and Chimney Emissions: Horizontal Coning
SPC 26 How Far Symptoms Travel: 25 Years, 500 Locations, 22 States
SPC 27 Not Into That Kind of Entertaining
SPC 28 Does it Cost More Than Money?
SPC 29 Airway to Systemic: Dysfunction of Detox Enzymes - Terlecky
SPC 30 Airway to systemic: Dysfunction of Detox Enzymes - Khatsenko
SPC 31 Gerde and Stadler: Benzo[a]pyrene Forever?
SPC 32 Phase I and II Detox Enzymes Defined

Lifestyle Change
SPC 33 ACA Catastrophic Consequences
SPC 34 Impossibly Good City Design
SPC 35 South Pole CAR Test: Satisfaction Guarantee

MCS 3 Definition and Concensus Criteria

MCS 3a Criteria Amendment Research Points (CAR)

MCS 3aa Etiology: Concensus Author CAR Test (SPC)

MCS 3b CAR References

SPC 13 Exposed Sensory Nerves - TRPA1

Please choose the Incorrect Statement

SPC 13a)

TRPA1 expressing peptidergic terminals, c fiber nerves, sensory receptors, nociceptors, primary afferents, unmyelinated c fibers - synonymously referring to the initiating point of inflammatory response. Peptidergic includes release of neuropeptide (neurotransmitter) inflammatory mediator substance P.

SPC 13b)
Once MCS is established - airway damage - permanent alterations - exposed TRPA1 expressing sensory receptors - whether from the continuous ACA or other exposure - at that point - activation of TRPA1 supports the disease process - an equal opportunity receptor to a broad range of chemicals.

SPC 13c)
MCS response is often masked - continuous exposure including the ACA lacking distinction - the baseline upon which other exposures are judged - straws on the camel's back - perception of relative significance turned backwards overlooking thousands of chemicals - many adsorbed on PM - potent stimulators of TRPA1 - supporting the MCS disease process.

SPC 13d)
The most qualified researchers in the world have shown that deenervation, genetic deletion, or pharmacological channel inhibition of TRPA1 impairs inflammatory release (Nassini 2011, Caceres 2009, Bessac 2008, Bautista 2006, Veronesi 2001) and the ACA has PM and gas phase components that potently stimulate TRPA1 - releasing cytokines and neuropeptides upon which the multi-organ systemic inflammatory process of MCS depends (Deering-Rice 2011, Hazari 2011, Costa 2010, Taylor-Clark 2010, Caceres 2009, Anand 2008, Bessac 2008), Nassenstein 2008, Bautista 2006, Inoue 2005, Kobayashi 2005, Veronesi 2001).

SPC 13e)
People like fireplaces, woodstoves, and combustion fueled transportation. It is best to present MCS as a syndrome in response to unrelated chemicals in a non inciting background atmosphere. It is not profitable to worry about ACA catastrophic consequences - geopolitical turmoil, overpopulation: 4.4 billion 1960/2015 - 3 to 7.4 billion in just 55 years (Worldometers 2015), resource loss, climate change, ocean acidification, mass extinction, speed, violence, pollution - injury, illness, and premature death.

Lifestyle Change
SPC 33 ACA Catastrophic Consequences
SPC 34 Impossibly Good City Design
SPC 35 South Pole CAR Test: Satisfaction Guarantee

MCS 3 Definition and Concensus Criteria

MCS 3a Criteria Amendment Research Points (CAR)

MCS 3aa Etiology: Concensus Author CAR Test (SPC)

MCS 3b CAR References

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SPC 13 Exposed Sensory Nerves - TRPA1

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