Airway Genetics and Ambient Combustion Aerosol

SPC 15 ACA: Loud and Clear

SPC 15 ACA: Loud and Clear

Links: 35 CAR Test SPC Questions
CAR Warm Up
SPC 1 Introduction: South Pole CAR (SPC) - A Character Test
SPC 2 South Pole CAR: ACA PM, Band Cell, and Monocyte Drop
SPC 3 ACA PM and ME/CFS: Do We Hear An Echo?
SPC 4 ACA UFPM: In the RBC - Through the BBB
SPC 5 ACA UFPM: IL-1 beta, RBC, BBB, - MCS and ME/CFS
SPC 6 ACA UFPM: Nerve Penetration
SPC 7 ACA UFPM: Olfactory, BBB, AD, PD, MCS, and ME/CFS
SPC 8 ACA PM: Gastro-Inflammation, Immunity, Vagal Circuitry
SPC 9 Veronesi: Sensory Nerve Insight
SPC 10 Kimata: Histamine Warning - Return to Masking
SPC 11 Central Sensitization: Intense, Repeated, and Sustained Inputs

On CAR
SPC 12 Disease Conditions Begin: Airway Epithelial Injury
SPC 13 Exposed Sensory Nerves - TRPA1
SPC 14 Exposed TRPA1: Central Sensitization
SPC 15 ACA: Loud and Clear
SPC 16 Airway Cytokine Release: Principle Mediator of Systemic Inflammation
SPC 17 Calderon-Garciduenas: Airway to Systemic: Putting It Together
SPC 18 Airway Gaps - Exposed Nerves - UFPM to the CNS
SPC 19 ACA PM: Months and Years Residence Time
SPC 20 Airway Gaps: Reduced Detox Enzyme Intervention
SPC 21 Solvents and Pesticides Primary: Shoe Fits Glove?
SPC 22 Veronesi and Roy: Genetic Difference in Airway Sensitivity

SPC 23 Jung Was Right Sort Of
SPC 24 Veronesi and Jung: A Perfect Match
SPC 25 Tailpipe and Chimney Emissions: Horizontal Coning
SPC 26 How Far Symptoms Travel: 25 Years, 500 Locations, 22 States
SPC 27 Not Into That Kind of Entertaining
SPC 28 Does it Cost More Than Money?
SPC 29 Airway to Systemic: Dysfunction of Detox Enzymes - Terlecky
SPC 30 Airway to systemic: Dysfunction of Detox Enzymes - Khatsenko
SPC 31 Gerde and Stadler: Benzo[a]pyrene Forever?
SPC 32 Phase I and II Detox Enzymes Defined

Lifestyle Change
SPC 33 ACA Catastrophic Consequences
SPC 34 Impossibly Good City Design
SPC 35 South Pole CAR Test: Satisfaction Guarantee

MCS 3 Definition and Consensus Criteria

MCS 3a Criteria Amendment Research Points (CAR)

MCS 3aa Etiology: Consensus Author CAR Test (SPC)

MCS 3b CAR References

SPC 15 ACA: Loud and Clear

Please choose the Incorrect Statement

SPC 15a)

The ambient combustion aerosol (ACA) - though not always the primary cause of disease initiating airway breakdown - will support existing disease process by acting upon exposed sensory nerve receptors, immune and epithelial cells in damaged airway epithelium increasing inflammatory mediator release (Hiraiwa 2014, 2013, Hogg 2009, Calderon-Garciduenas 2008, 2003, 2001 Goto 2004, Mukae 2001, Veronesi 2001, Meggs 1997), providing input for central sensitization (Latremoliere 2009) and direct penetration of ACA UFPM (ultra fine particulate matter less than .1 micron) and PM 2.5 via neural and other systemic pathways (Block 2012, Calderon-Garciduenas 2010, 2008, Genter 2009, Matsui 2009, Elder 2006, Lewis 2005) - disease condition is one of permanent gaps in the epithelium - lacking physical barrier and detox enzyme activity ahead of potential nerve contact and deeper penetration (Block 2012, Calderon-Garciduenas 2010, 2008, Baulig 2009, 2003a, Genter 2009, Matsui 2009, Elder 2006, Lewis 2005, Bonvallot 2001, 2000, Gerde 2001, 1997).

SPC 15b)

Something is supporting the ongoing neurogenic inflammation evidenced by respiratory cell tight junction defects, focal desquamation of epithelial cells, hypertrophy of glandular structures, lymphocytic infiltrates, and proliferation of nerve fibers (Meggs 1997) - high levels of nerve growth factor (NGF), substance P (SP), and vasoactive intestinal peptide VIP ( Kimata 2004), altered cytokine profile (Dantoft 2014), elevated nitric oxide (NO), severe glutathione depletion, catalase deficiency, and proatherogenic lipid changes (Deluca 2010, Baldwin 1998), SPECT hypoactivity (Orriols 2009), and electroencephalographic alterations (Bell 1998, 1996) - all at baseline - before or without study provocation.