Airway Genetics and Ambient Combustion Aerosol

SPC 4 ACA UFPM: In the RBC - Through the BBB

SPC 4 ACA UFPM: In the RBC - Through the BBB

Links: 35 CAR Test SPC Questions
CAR Warm Up
SPC 1 Introduction: South Pole CAR (SPC) - A Character Test
SPC 2 South Pole CAR: ACA PM, Band Cell, and Monocyte Drop
SPC 3 ACA PM and ME/CFS: Do We Hear An Echo?
SPC 4 ACA UFPM: In the RBC - Through the BBB
SPC 5 ACA UFPM: IL-1 beta, RBC, BBB, - MCS and ME/CFS
SPC 6 ACA UFPM: Nerve Penetration
SPC 7 ACA UFPM: Olfactory, BBB, AD, PD, MCS, and ME/CFS
SPC 8 ACA PM: Gastro-Inflammation, Immunity, Vagal Circuitry
SPC 9 Veronesi: Sensory Nerve Insight
SPC 10 Kimata: Histamine Warning - Return to Masking
SPC 11 Central Sensitization: Intense, Repeated, and Sustained Inputs

On CAR
SPC 12 Disease Conditions Begin: Airway Epithelial Injury
SPC 13 Exposed Sensory Nerves - TRPA1
SPC 14 Exposed TRPA1: Central Sensitization
SPC 15 ACA: Loud and Clear
SPC 16 Airway Cytokine Release: Principle Mediator of Systemic Inflammation
SPC 17 Calderon-Garciduenas: Airway to Systemic: Putting It Together
SPC 18 Airway Gaps - Exposed Nerves - UFPM to the CNS
SPC 19 ACA PM: Months and Years Residence Time
SPC 20 Airway Gaps: Reduced Detox Enzyme Intervention
SPC 21 Solvents and Pesticides Primary: Shoe Fits Glove?
SPC 22 Veronesi and Roy: Genetic Difference in Airway Sensitivity

SPC 23 Jung Was Right Sort Of

SPC 24 Veronesi and Jung: A Perfect Match
SPC 25 Tailpipe and Chimney Emissions: Horizontal Coning
SPC 26 How Far Symptoms Travel: 25 Years, 500 Locations, 22 States
SPC 27 Not Into That Kind of Entertaining
SPC 28 Does it Cost More Than Money?
SPC 29 Airway to Systemic: Dysfunction of Detox Enzymes - Terlecky
SPC 30 Airway to systemic: Dysfunction of Detox Enzymes - Khatsenko
SPC 31 Gerde and Stadler: Benzo[a]pyrene Forever?
SPC 32 Phase I and II Detox Enzymes Defined

Lifestyle Change
SPC 33 ACA Catastrophic Consequences
SPC 34 Impossibly Good City Design
SPC 35 South Pole CAR Test: Satisfaction Guarantee

MCS 3 Definition and Consensus Criteria

MCS 3a Criteria Amendment Research Points (CAR)

MCS 3aa Etiology: Consensus Author CAR Test (SPC)

MCS 3b CAR References

SPC 4 ACA UFPM: In the RBC - Through the BBB

Please choose the Incorrect Statement

SPC 4a)

erythrocyte (red blood cell), leukocyte (white blood cell), endothelial (of blood vessel wall), capillaries (fine blood vessels)

SPC 4b)

CALDERON-GARCIDUENAS 2008:
"...Olfactory bulb (OB) neurons in the glomerular region exhibit abundant particulate matter (PM) in their cytoplasm in a fourteen-year-old Mexico City (MC) boy...
...Peribronchial lymph node in a seventeen-year old male MC nonsmoker. There are numerous macrophages in the cortical zone with black particulate matter. The afferent lymphatics also exhibit abundant PM-loaded macrophages...
...Kuppffer cells (liver macrophages) loaded with PM in the liver of a thirty-two-year old MC resident...
...thirty-three-year old male MC resident. PMNs (polymorphonuclear leukocytes) are seen attached to endothelial cells in lung capillaries, in keeping with endothelial activation...
...twenty-four-year old female MC resident...The endothelial cell lining of the lung capillary exhibits elongated fronds that surround a luminal erythrocyte (red blood cell). The endothelial fronds completely embrace the erythrocyte (12,000Xmag)...close association between the cytoplasm of the endothelial cell and the erythrocyte with aggregation of particulate matter at the interface (25,000Xmag)...same lung capillary showing the relationship between the endothelial cell membrane-bound structure with ultrafine PM and the erythrocyte (RBC) surface (50,000Xmag)...An erythrocyte (RBC) in the lumen of a lung capillary exhibits numerous nanosized particulate material (50,000Xmag)...

SPC 4c)
...two critical observations were described in this human study: the presence of UFPM in RBCs and the aggregation of intramembrane particles with the formation of patterned discrete contact points between endothelial cells and RBCs in the CNS, trigeminal ganglia, and lung capillaries...pathway for the exchange of PM between the activated endothelial cell and the UFPM-loaded RBCs in keeping with the capacity of ultrafine PM to penetrate RBC...(Rothen-Rutishauser 2006, Geiser 2005).

Ultrafine particles are not membrane bound which allows for direct access to intracellular proteins, organelles, and DNA, enhancing there toxic potential (Geiser 2005). Further, the passage of PM to the brain following the RBC-activated endothelial cell is likely to be increased in subjects exposed to pollutants owing to the disruption of the BBB (blood-brain barrier)...

SPC 4d)
...The presence of PM in olfactory bulb neurons, in luminal erythrocytes from capillaries in lung, frontal and trigeminal ganglia, and in Kupffer cells, along with the translocation of UFPM from RBC to endothelial cells in capillary lungs, and from RBC to endothelial cells and to perivascular macrophage-like cells in frontal capillaries are very important findings in these highly exposed individuals. The fact that PM is directly reaching the brain parenchyma, along with the early disruption of the BBB and the vagal upregulation of CD 14 (LPS receptor) capable of activating inflammatory processes in the brainstem are key findings...

SPC 4e)
...the upregulation of CD 14 (LPS receptor)...particularly those exposed to significant amounts of PM-associated LPS..."

BLOCK 2004:
"...LPS (lipopolysaccharide endotoxin) is one of the common chemicals adsorbed on the surface of DEP (diesel exhaust particles) (Ma 2002)..."

SPC 4f)
CALDERON-GARCIDUENAS 2008:
"...brain oxidative stress starts in childhood and the teen years...in the scenario of air pollution exposure...progressive neurodegeneration that develops insidiously over the lifetime of the individual (McGeer 2006, Jellinger 2003, Nguyen 2002, Selkoe 2002, 2001)..."

SPC 4g)
We love our cars and trucks - UFPM everywhere - lymph nodes, olfactory bulb, Kupffer cells (liver macrophages), red blood cells, and brain parenchyma - but thats okay - happy motoring - we are all for it. 12, 25, and 50,000 X magnification places UFPM in red blood cells nearly caught in the act - transferring UFPM to endothelial cells - pressing for opportunity through the BBB. So we have diesel in our heads - leading to catastrophic illness for some - and dismal for others. Why walk and use low speed, injury proof, zero emission vehicles - when we can drive cars and trucks to destroy personal health and end life on earth.

Links: 35 CAR Test SPC Questions

CAR Warm Up

SPC 1 Introduction: South Pole CAR (SPC) - A Character Test
SPC 2 South Pole CAR: ACA PM, Band Cell, and Monocyte Drop
SPC 3 ACA PM and ME/CFS: Do We Hear An Echo?
SPC 4 ACA UFPM: In the RBC - Through the BBB
SPC 5 ACA UFPM: IL-1 beta, RBC, BBB, - MCS and ME/CFS
SPC 6 ACA UFPM: Nerve Penetration
SPC 7 ACA UFPM: Olfactory, BBB, AD, PD, MCS, and ME/CFS
SPC 8 ACA PM: Gastro-Inflammation, Immunity, Vagal Circuitry
SPC 9 Veronesi: Sensory Nerve Insight
SPC 10 Kimata: Histamine Warning - Return to Masking
SPC 11 Central Sensitization: Intense, Repeated, and Sustained Inputs

SPC 23 Jung Was Right Sort Of
SPC 24 Veronesi and Jung: A Perfect Match
SPC 25 Tailpipe and Chimney Emissions: Horizontal Coning
SPC 26 How Far Symptoms Travel: 25 Years, 500 Locations, 22 States
SPC 27 Not Into That Kind of Entertaining
SPC 28 Does it Cost More Than Money?
SPC 29 Airway to Systemic: Dysfunction of Detox Enzymes - Terlecky
SPC 30 Airway to systemic: Dysfunction of Detox Enzymes - Khatsenko
SPC 31 Gerde and Stadler: Benzo[a]pyrene Forever?
SPC 32 Phase I and II Detox Enzymes Defined

Lifestyle Change
SPC 33 ACA Catastrophic Consequences
SPC 34 Impossibly Good City Design
SPC 35 South Pole CAR Test: Satisfaction Guarantee

MCS 3 Definition and Concensus Criteria

MCS 3a Criteria Amendment Research Points (CAR)

MCS 3aa Etiology: Concensus Author CAR Test (SPC)

MCS 3b CAR References

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SPC 4 ACA UFPM: In the RBC - Through the BBB

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